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A5384: A Phase II, Randomized, Open-Label Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents with Tuberculous Meningitis

Study Description A5384 is a trial for people who have or might have tuberculous meningitis (TBM). TBM is an infectious…

Open and enrolling

Tuberculosis

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A5409: A Phase 2 Randomized, Adaptive, Dose-Ranging, Open-Label Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis (RAD-TB)

The standard of care (SOC) treatment of tuberculosis (TB) was developed over 40 years ago, and the treatment is long…

Open and enrolling

Tuberculosis

Participants will be in this study for about 52 weeks. This includes a total of 26 weeks of TB treatment. If assigned to the experimental arm, participants will have 8 weeks of experimental treatment, followed by 18 weeks of SOC treatment. If assigned to the SOC arm, participants will have 26 weeks of SOC treatment.

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