Los Angeles, Calif. – The AIDS Clinical Trials Group (ACTG), the world’s largest HIV research network, today announced the publication of “Varied Patterns of Decay of Intact HIV-1 Proviruses over Two Decades of ART” in the Journal of Infectious Diseases. This publication found that levels of intact proviral DNA (inactive HIV DNA that may be capable of replicating) initially decay rapidly but that decay markedly slows among virally suppressed people living with HIV on long-term ART. The study also found a late increase in proviral DNA levels among some individuals. These data suggest that if the decay rates during the second phase could be accelerated to more closely approximate the first phase, it may be possible to reduce the viral reservoir to the degree needed to achieve HIV remission.
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