MU-JHU Research Collaboration (MUJHU CARE LTD) CRS

To find out whether tuberculosis (TB) can be treated safely within a shorter time using newer medicines and whether the new treatment works as well as, or better than, the standard 6-month TB treatment, and to look at whether these treatments are safe and effective for adolescents.

Tuberculosis

Closed to accrual

A5300B/I2003B: PHOENIx MDR TB Household Prevention

This trial is in household contacts (HHC) at high risk for developing multidrug resistant tuberculosis (MDR-TB) which is an infection that does not get better with standard treatment for TB. HHC means any person that lives with, has lived with, or shared housekeeping duties in a home or the same place with a person (an Index Case) who has pulmonary MDR-TB (a lung infection or pneumonia with TB) and started treatment for MDR-TB within the past 90 days. It is also for people who have spent more than 4 hours indoors with the index case, during the week before they started MDR-TB treatment.

High-risk household contacts are those with HIV or an immune system problem not from HIV like cancer , latent TB infection (a history of TB infection in the past based on testing), and young children below the age of 5 years.