Research Area HIV Cure

A5413: Dasatinib for HIV-1 Reservoir Reduction

To determine if dasatinib is safe and well tolerated in people with HIV, and to see if dasatinib can reduce…

Open and enrolling

36 weeks

• Study Treatment: 12 Weeks
• Follow-up: 24 Weeks

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A5428: Small Trial of Alendronate Impact on the Reservoir of HIV (STAIR-HIV)

Though antiretroviral therapy (ART) is very effective at suppressing the HIV virus, it is, however, unable to totally remove it…

Open and enrolling

Participants will be in this study for about 44 weeks; this includes:

• 12 weeks for pre-intervention evaluations
• 24 weeks of study treatment
• 8 weeks of follow-up after stopping study treatment

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A5389: Two bNAb Combination for Acute HIV-1 Infection

This study will evaluate the combination of two experimental broadly neutralizing antibodies (bNAbs) in participants who started anti-HIV medications (also…

Active, Not Recruiting

The maximum time you will be in the study is about 98 weeks.

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A5341s: Size and Decay of HIV-1 Reservoirs in Tissues and Cerebrospinal Fluid in Participants on Long-Term Antiretroviral Therapy: A substudy of the ACTG HIV Reservoirs Cohort (AHRC) Study

A5341s: A5321 Sampling Substudy   Longitudinal Sampling Substudy of A5321 is collecting information from measures of different HIV reservoirs, including…

Closed to accrual

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A5354: Effect of Antiretroviral Treatment Initiated During Acute HIV-1 Infection on Measures of HIV-1 Persistence and on HIV-1-Specific Immune Responses

Will evaluate whether starting antiretroviral drugs very early in HIV infection will limit the virus from getting into hidden areas…

Closed to accrual

The duration of the study is up to 72 weeks (a year and a half).

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A5321: Decay of HIV-1 Reservoirs in Participants on Long-Term ART

AHRC (pronounced “ARC”) is a study of differences and changes over time in HIV reservoirs (groups of HIV-infected cells that…

Closed to accrual

Participants will be expected to stay in the study for about 7 years.

 

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A5128: Plan for Obtaining Informed Consent to use Stored Human Biological Materials (HBM) for Currently Unspecified Analysis.

Designed to develop a standard operating procedure to establish a storage bank for specimens for future HIV DNA analyses. Informed…

Closed to accrual

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