Trials Open to Enrollment

Categories of Trials

The ACTG conducts offers a wide range of studies for people infected with HIV. Clinical trials that are currently Open to Enrollment are listed by Category below. For each trial in the category, a link to more detailed information about the study will be provided.

Please scroll down to select from the Study Categories to see the types of trials. You may also view a list of all studies.

Treatment Naïve

Treatment Naïve refers to people who have never taken HIV medications before. These studies are designed to help find out what treatments or drugs work best as an initial regimen.

Treatment Experienced

Treatment Experienced refers to people who are currently on medications or have taken medications in the past for HIV. Each study has a unique approach: Which are the best medications to treat with? When is the best time to change medications? How do we know when to change medications?

Immunity Enhancers

HIV harms the immune system. These studies look at innovative ways to help your immune system work better while continuing to treat you with HIV medications.


Women with HIV have unique gynecology, maternity, and metabolic issues. These studies are dedicated to fostering the health of women.

Opportunistic Infections

When people with HIV have an additional infection like cytomegalovirus or tuberculosis, there are important treatment questions and side effects to look for. These studies are looking at that unique situation.


People with HIV may also be infected with Hepatitis. These trials study the treatment of individuals with Hepatitis or individuals with Hepatitis and HIV.

Neurologic Complications

HIV infection may cause nervous system problems such as numbness and cognitive problems. These studies look at treatments for the problems.

Side Effects

We know that many drugs used to successfully treat HIV have side effects. The following studies look at ways to treat the most common of these side effects.


People with HIV may also be infected with Tuberculosis. These trials study the diagnosis and treatment of individuals with Tuberculosis.


Studies in this section are those in which no attempt is made to affect the outcome of HIV treatment, for example, no treatment is prescribed or provided by the study. People who enter these studies may be asked to provide blood or other biological specimens. They may be asked to complete clinical evaluations and questionnaires. The information from these studies might prove useful in evaluating current or future treatment for people living with HIV.


People with HIV may also be infected with Malaria. These trials study the treatment of individuals with Malaria or individuals with Malaria and HIV.

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