Study Category of Trial Enrollment Status
A5128: US Genomic Sampling
Designed to develop a standard operating procedure to establish a storage bank for specimens for future HIV DNA analyses.
Non-Interventional Open and Enrolling
A5243: Non-US Genomic Sampling
Collecting blood and saliva samples from former and current ACTG study participants for future HIV-related genetic testing.
Non-Interventional Open and Enrolling
A5321: Decay of HIV-1 Reservoirs in Participants on Long-Term Antiretroviral Therapy: The ACTG HIV Reservoirs Cohort (AHRC) Study
Studies differences and changes over time in HIV reservoirs (groups of HIV infected cells that ’hide’ from anti-HIV medications).
Treatment Experienced Open and Enrolling
A5345: HIV Rebound & Control Biomarkers
Uses data collected during intensively monitored antiretroviral pauses, where participants stop taking anti-HIV medications until they meet criteria for restarting them.
Treatment Experienced Closed to Accrual
A5354: Early ART in Acute HIV
Will evaluate whether starting antiretroviral drugs very early in HIV infection will limit the virus from getting into hidden areas of the body (reservoirs) and change how the immune system helps to control the virus.
Treatment Naïve Closed to Accrual
A5357: A Study of Long-Acting Cabotegravir Plus VRC01LS to Maintain Viral Suppression in HIV-1-Infected Adults
Study Description This study is for people with HIV who have an undetectable viral load.
Treatment Experienced
A5359: The LATITUDE Study
Investigating whether long-acting injectable medications will be more successful for people who are non-adherent to their HIV medications than oral regimens.
Treatment Experienced Open and Enrolling
A5368:Anti-PD-1 Antibody in HBV Infected on Suppressive Antiviral Therapy
“Safety and Immunotherapeutic Activity of Cemiplimab in Participants with HBV on Suppressive Antiviral Therapy: A Phase I/II Ascending Multiple Dose Study” Brief Description: Scientists are looking at ways to cure Hepatitis B (HBV).
Open and Enrolling
A5369: p24CE Vaccine Study
Evaluating the safety and effectiveness of a new HIV vaccine.
Treatment Experienced Closed to Accrual
A5375: Optimize LNG EC
Will determine if a higher dose of levonorgestrel Emergency Contraception (commonly called “Plan B” or the “Morning After Pill”) is needed to achieve high enough drug levels in girls and women who are taking anti-HIV medications that are known to decrease the effectiveness of this form of birth control.
Treatment Experienced
A5377: Tri-specific Antibody
The first study of a broadly neutralizing antibody called SAR441236 in humans, will determine if an infusion is safe and tolerable and will measure the amount of SAR441236 in the blood over time.
Treatment NaïveTreatment Experienced

Categories of Trials

The ACTG conducts offers a wide range of studies for people infected with HIV. Below is a list of different kinds of clinical trials.

Treatment Naïve

Treatment Naïve refers to people who have never taken HIV medications before. These studies are designed to help find out what treatments or drugs work best as an initial regimen.

Treatment Experienced

Treatment Experienced refers to people who are currently on medications or have taken medications in the past for HIV. Each study has a unique approach: Which are the best medications to treat with? When is the best time to change medications? How do we know when to change medications?

Immunity Enhancers

HIV harms the immune system. These studies look at innovative ways to help your immune system work better while continuing to treat you with HIV medications.


Women with HIV have unique gynecology, maternity, and metabolic issues. These studies are dedicated to fostering the health of women.

Opportunistic Infections

When people with HIV have an additional infection like cytomegalovirus or tuberculosis, there are important treatment questions and side effects to look for. These studies are looking at that unique situation.


People with HIV may also be infected with Hepatitis. These trials study the treatment of individuals with Hepatitis or individuals with Hepatitis and HIV.

Neurologic Complications

HIV infection may cause nervous system problems such as numbness and cognitive problems. These studies look at treatments for the problems.

Side Effects

We know that many drugs used to successfully treat HIV have side effects. The following studies look at ways to treat the most common of these side effects.


People with HIV may also be infected with Tuberculosis. These trials study the diagnosis and treatment of individuals with Tuberculosis.


Studies in this section are those in which no attempt is made to affect the outcome of HIV treatment, for example, no treatment is prescribed or provided by the study. People who enter these studies may be asked to provide blood or other biological specimens. They may be asked to complete clinical evaluations and questionnaires. The information from these studies might prove useful in evaluating current or future treatment for people living with HIV.


People with HIV may also be infected with Malaria. These trials study the treatment of individuals with Malaria or individuals with Malaria and HIV.