ACTG Publications

TitleAuthorsDateJournalIssueVolume
Antiretroviral concentrations in hair strongly predict virologic response in a large HIV treatment-naive clinical trial.Gandhi, Monica ; Ofokotun, Igho ; Bacchetti, Peter ; Jin, Chengshi ; Ribaudo, Heather J ; Haas, David W ; Sheth, Anandi N ; Horng, Howard ; Phung, Nhi ; Kuncze, Karen ; Okochi, Hideaki ; Landovitz, Raphael J ; Lennox, Jeffrey ; Currier, Judith S ; AIDS Clinical Trials Group (ACTG) 5257 study team2018 Sep 03Clin Infect Dis
Body Composition Changes After Initiation of Raltegravir or Protease Inhibitors: ACTG A5260s.McComsey, Grace A ; Moser, Carlee ; Currier, Judith ; Ribaudo, Heather J ; Paczuski, Pawel ; Dubé, Michael P ; Kelesidis, Theodoros ; Rothenberg, Jennifer ; Stein, James H ; Brown, Todd T2016 Apr 1Clin Infect Dis762
Body composition, soluble markers of inflammation, and bone mineral density in antiretroviral therapy-naive HIV-1-infected individuals.Brown, Todd T ; Chen, Yun ; Currier, Judith S ; Ribaudo, Heather J ; Rothenberg, Jennifer ; Dubé, Michael P ; Murphy, Robert ; Stein, James H ; McComsey, Grace A2013 Jul 1J Acquir Immune Defic Syndr363
Change in high-sensitivity c-reactive protein levels following initiation of efavirenz-based antiretroviral regimens in HIV-infected individuals.Shikuma, Cecilia M ; Ribaudo, Heather J ; Zheng, Yu ; Gulick, Roy M ; Meyer, William A ; Tashima, Karen T ; Bastow, Barbara ; Kuritzkes, Daniel R ; Glesby, Marshall J ; AIDS Clinical Trials Group A5095 Study Team2011 MayAIDS Res Hum Retroviruses527
Changes in Bone Mineral Density After Initiation of Antiretroviral Treatment With Tenofovir Disoproxil Fumarate/Emtricitabine Plus Atazanavir/Ritonavir, Darunavir/Ritonavir, or Raltegravir.Brown, Todd T ; Moser, Carlee ; Currier, Judith S ; Ribaudo, Heather J ; Rothenberg, Jennifer ; Kelesidis, Theodoros ; Yang, Otto ; Dubé, Michael P ; Murphy, Robert L ; Stein, James H ; McComsey, Grace A2015 Oct 15J Infect Dis8212
Changes in Inflammation and Immune Activation With Atazanavir-, Raltegravir-, Darunavir-Based Initial Antiviral Therapy: ACTG 5260s.Kelesidis, Theodoros ; Tran, Thuy Tien T ; Stein, James H ; Brown, Todd T ; Moser, Carlee ; Ribaudo, Heather J ; Dubé, Michael P ; Murphy, Robert ; Yang, Otto O ; Currier, Judith S ; McComsey, Grace A2015 Aug 15Clin Infect Dis461
Changes in Markers of T-Cell Senescence and Exhaustion With Atazanavir-, Raltegravir-, and Darunavir-Based Initial Antiviral Therapy: ACTG 5260s.Kelesidis, Theodoros ; Moser, Carlee ; Stein, James H ; Brown, Todd T ; Tran, Thuy Tien T ; Ribaudo, Heather J ; Dubé, Michael P ; Yang, Otto O ; Currier, Judith S ; McComsey, Grace A2016 Jun 28J Infect Dis
Changes in plasma levels of oxidized lipoproteins and lipoprotein subfractions with atazanavir-, raltegravir-, darunavir-based initial antiviral therapy and associations with common carotid artery intima-media thickness: ACTG 5260s.Kelesidis, Theodoros ; Tran, Thuy Tien T ; Brown, Todd T ; Moser, Carlee ; Ribaudo, Heather J ; Dubé, Michael P ; Yang, Otto O ; McComsey, Grace A ; Stein, James H ; Currier, Judith S2016 Sep 23Antivir Ther
Clinical and genetic determinants of plasma nevirapine exposure following an intrapartum dose to prevent mother-to-child HIV transmission.Vardhanabhuti, Saran ; Acosta, Edward P ; Ribaudo, Heather J ; Severe, Patrice ; Lalloo, Umesh ; Kumarasamy, Nagalingeshwaran ; Taulo, Frank ; Kabanda, Joseph ; Oneko, Olola ; Ive, Prudence ; Sambarey, Pradeep ; Chan, Ellen S ; Hitti, Jane ; Hong, Francis ; McMahon, Deborah ; Haas, David W ; A5207 ACTG Study Team2013 Aug 15J Infect Dis4208
Comparative effectiveness of initial antiretroviral therapy regimens: ACTG 5095 and 5142 clinical trials relative to ART-CC cohort study.Mugavero, Michael J ; May, Margaret ; Ribaudo, Heather J ; Gulick, Roy M ; Riddler, Sharon A ; Haubrich, Richard ; Napravnik, Sonia ; Abgrall, Sophie ; Phillips, Andrew ; Harris, Ross ; Gill, M John ; de Wolf, Frank ; Hogg, Robert ; Günthard, Huldrych F ; Chêne, Geneviève ; D'Arminio Monforte, Antonella ; Guest, Jodie L ; Smith, Colette ; 2011 Nov 1J Acquir Immune Defic Syndr358
Comparison of the metabolic effects of ritonavir-boosted darunavir or atazanavir versus raltegravir, and the impact of ritonavir plasma exposure: ACTG 5257.Ofotokun, Ighovwerha ; Na, Lumine H ; Landovitz, Raphael J ; Ribaudo, Heather J ; McComsey, Grace A ; Godfrey, Catherine ; Aweeka, Francesca ; Cohn, Susan E ; Sagar, Manish ; Kuritzkes, Daniel R ; Brown, Todd T ; Patterson, Kristine B ; Para, Michael F ; Leavitt, Randi Y ; Villasis-Keever, Angelina ; Baugh, Bryan P ; Lennox, Jeffrey L ; Cu2015 Jun 15Clin Infect Dis1260
Comparison of Three Different FDA-Approved Plasma HIV-1 RNA Assay Platforms Confirms the Virologic Failure Endpoint of 200 Copies per Milliliter Despite Improved Assay Sensitivity.Lalama, Christina M ; Jennings, Cheryl ; Johnson, Victoria A ; Coombs, Robert W ; McKinnon, John E ; Bremer, James W ; Cobb, Bryan R ; Cloherty, Gavin A ; Mellors, John W ; Ribaudo, Heather J ; AIDS Clinical Trials Group2015 AugJ Clin Microbiol853
A comparison of three initial antiretroviral AIDS regimens.Ribaudo, Heather J ; Kuritzkes, Daniel R ; Gulick, Roy M2007 Sep 6N Engl J Med10357
Design issues in initial HIV-treatment trials: focus on ACTG A5095.Ribaudo, Heather J ; Kuritzkes, Daniel R ; Schackman, Bruce R ; Acosta, Edward P ; Shikuma, Cecilia M ; Gulick, Roy M2006Antivir Ther611
Differential CD4+ cell count increase and CD4+ :  CD8+ ratio normalization with maraviroc compared with tenofovir.Chan, Ellen S ; Landay, Alan L ; Brown, Todd T ; Ribaudo, Heather J ; Mirmonsef, Paria ; Ofotokun, Igho ; Weitzmann, M Neale ; Martinson, Jeffrey ; Klingman, Karin L ; Eron, Joseph J ; Fichtenbaum, Carl J ; Plants, Jill ; Taiwo, Babafemi O2016 Aug 24AIDS1330
Efavirenz-based regimens in treatment-naive patients with a range of pretreatment HIV-1 RNA levels and CD4 cell counts.Ribaudo, Heather J ; Kuritzkes, Daniel R ; Lalama, Christina M ; Schouten, Jeffrey T ; Schackman, Bruce R ; Acosta, Edward P ; Gulick, Roy M2008 Apr 1J Infect Dis7197
Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study.Ribaudo, Heather J ; Liu, Huan ; Schwab, Matthias ; Schaeffeler, Elke ; Eichelbaum, Michel ; Motsinger-Reif, Alison A ; Ritchie, Marylyn D ; Zanger, Ulrich M ; Acosta, Edward P ; Morse, Gene D ; Gulick, Roy M ; Robbins, Gregory K ; Clifford, David ; Haas, David W2010 Sep 1J Infect Dis5202
Efficacy and tolerability of 3 nonnucleoside reverse transcriptase inhibitor-sparing antiretroviral regimens for treatment-naive volunteers infected with HIV-1: a randomized, controlled equivalence trial.Lennox, Jeffrey L ; Landovitz, Raphael J ; Ribaudo, Heather J ; Ofotokun, Ighovwerha ; Na, Lumine H ; Godfrey, Catherine ; Kuritzkes, Daniel R ; Sagar, Manish ; Brown, Todd T ; Cohn, Susan E ; McComsey, Grace A ; Aweeka, Francesca ; Fichtenbaum, Carl J ; Presti, Rachel M ; Koletar, Susan L ; Haas, David W ; Patterson, Kristine B ; Benson, 2014 Oct 7Ann Intern Med7161
Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants.Holzinger, Emily R ; Grady, Benjamin ; Ritchie, Marylyn D ; Ribaudo, Heather J ; Acosta, Edward P ; Morse, Gene D ; Gulick, Roy M ; Robbins, Gregory K ; Clifford, David B ; Daar, Eric S ; McLaren, Paul ; Haas, David W2012 DecPharmacogenet Genomics1222
Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols.Lehmann, David S ; Ribaudo, Heather J ; Daar, Eric S ; Gulick, Roy M ; Haubrich, Richard H ; Robbins, Gregory K ; DE Bakker, Paul I W ; Haas, David W ; McLaren, Paul J2015 FebPharmacogenet Genomics225
HIV Transmission Risk Behavior in a Cohort of HIV-Infected Treatment-Naïve Men and Women in the United States.Landovitz, Raphael J ; Tran, Thuy Tien T ; Cohn, Susan E ; Ofotokun, Ighovwhera ; Godfrey, Catherine ; Kuritzkes, Daniel R ; Lennox, Jeffrey L ; Currier, Judith S ; Ribaudo, Heather J2016 Mar 16AIDS Behav
Hyperlipidaemia in HIV-infected patients on lopinavir/ritonavir monotherapy in resource-limited settings.Matoga, Mitch M ; Hosseinipour, Mina C ; Aga, Evgenia ; Ribaudo, Heather J ; Kumarasamy, Nagalingeswaran ; Bartlett, John ; Hughes, Michael D ; ACTG A5230 Study Team2016 Oct 14Antivir Ther
Impact of minority nonnucleoside reverse transcriptase inhibitor resistance mutations on resistance genotype after virologic failure.Li, Jonathan Z ; Paredes, Roger ; Ribaudo, Heather J ; Kozal, Michael J ; Svarovskaia, Evguenia S ; Johnson, Jeffrey A ; Geretti, Anna Maria ; Metzner, Karin J ; Jakobsen, Martin R ; Hullsiek, Katherine Huppler ; Ostergaard, Lars ; Miller, Michael D ; Kuritzkes, Daniel R2013 Mar 15J Infect Dis6207
Impact of UGT1A1 Gilbert variant on discontinuation of ritonavir-boosted atazanavir in AIDS Clinical Trials Group Study A5202.Ribaudo, Heather J ; Daar, Eric S ; Tierney, Camlin ; Morse, Gene D ; Mollan, Katie ; Sax, Paul E ; Fischl, Margaret A ; Collier, Ann C ; Haas, David W ; DS Clinical Trials Group2013 Feb 1J Infect Dis3207
Instantaneous inhibitory potential is similar to inhibitory quotient at predicting HIV-1 response to antiretroviral therapy.Henrich, Timothy J ; Ribaudo, Heather J ; Kuritzkes, Daniel R2010 Jul 1Clin Infect Dis151
Intensification of a triple-nucleoside regimen with tenofovir or efavirenz in HIV-1-infected patients with virological suppression.Gulick, Roy M ; Lalama, Christina M ; Ribaudo, Heather J ; Shikuma, Cecilia M ; Schackman, Bruce R ; Schouten, Jeffrey ; Squires, Kathleen E ; Koletar, Susan L ; Pilcher, Christopher D ; Reichman, Richard C ; Klingman, Karin L ; Kuritzkes, Daniel R2007 Apr 23AIDS721
Lopinavir/ritonavir monotherapy after virologic failure of first-line antiretroviral therapy in resource-limited settings.Bartlett, John A ; Ribaudo, Heather J ; Wallis, Carole L ; Aga, Evgenia ; Katzenstein, David A ; Stevens, Wendy S ; Norton, Michael R ; Klingman, Karin L ; Hosseinipour, Mina C ; Crump, John A ; Supparatpinyo, Khuanchai ; Badal-Faesen, Sharlaa ; Kallungal, Beatrice A ; Kumarasamy, Nagalingeswaran2012 Jul 17AIDS1126
Lopinavir/Ritonavir Monotherapy as Second-line Antiretroviral Treatment in Resource-Limited Settings: Week 104 Analysis of AIDS Clinical Trials Group (ACTG) A5230.Kumarasamy, Nagalingeswaran ; Aga, Evgenia ; Ribaudo, Heather J ; Wallis, Carole L ; Katzenstein, David A ; Stevens, Wendy S ; Norton, Michael R ; Klingman, Karin L ; Hosseinipour, Mina C ; Crump, John A ; Supparatpinyo, Khuanchai ; Badal-Faesen, Sharlaa ; Bartlett, John A2015 May 15Clin Infect Dis1060
Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis.Li, Jonathan Z ; Paredes, Roger ; Ribaudo, Heather J ; Svarovskaia, Evguenia S ; Metzner, Karin J ; Kozal, Michael J ; Hullsiek, Kathy Huppler ; Balduin, Melanie ; Jakobsen, Martin R ; Geretti, Anna Maria ; Thiebaut, Rodolphe ; Ostergaard, Lars ; Masquelier, Bernard ; Johnson, Jeffrey A ; Miller, Michael D ; Kuritzkes, Daniel R2011 Apr 6JAMA13305
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.International HIV Controllers Study ; Pereyra, Florencia ; Jia, Xiaoming ; McLaren, Paul J ; Telenti, Amalio ; DE Bakker, Paul I W ; Walker, Bruce D ; Ripke, Stephan ; Brumme, Chanson J ; Pulit, Sara L ; Carrington, Mary ; Kadie, Carl M ; Carlson, Jonathan M ; Heckerman, David ; Graham, Robert R ; Plenge, Robert M ; Deeks, Steven G ; Giann2010 Dec 10Science6010330
Metabolic effects of protease inhibitor-sparing antiretroviral regimens given as initial treatment of HIV-1 Infection (AIDS Clinical Trials Group Study A5095).Shikuma, Cecilia M ; Yang, Yang ; Glesby, Marshall J ; Meyer, William A ; Tashima, Karen T ; Ribaudo, Heather J ; Webb, Nancy ; Bastow, Barbara ; Kuritzkes, Daniel R ; Gulick, Roy M2007 Apr 15J Acquir Immune Defic Syndr544
No risk of myocardial infarction associated with initial antiretroviral treatment containing abacavir: short and long-term results from ACTG A5001/ALLRT.Ribaudo, Heather J ; Benson, Constance A ; Zheng, Yu ; Koletar, Susan L ; Collier, Ann C ; Lok, Judith J ; Smurzynski, Marlene ; Bosch, Ronald J ; Bastow, Barbara ; Schouten, Jeffrey T ; ACTG A5001/ALLRT Protocol Team2011 Apr 1Clin Infect Dis752
Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: an Adult AIDS Clinical Trials Group Study.Ribaudo, Heather J ; Haas, David W ; Tierney, Camlin ; Kim, Richard B ; Wilkinson, Grant R ; Gulick, Roy M ; Clifford, David B ; Marzolini, Catia ; Fletcher, Courtney V ; Tashima, Karen T ; Kuritzkes, Daniel R ; Acosta, Edward P ; Adult AIDS Clinical Trials Group Study2006 Feb 1Clin Infect Dis342
Plasma HIV-1 RNA dynamics in antiretroviral-naive subjects receiving either triple-nucleoside or efavirenz-containing regimens: ACTG A5166s.Kuritzkes, Daniel R ; Ribaudo, Heather J ; Squires, Kathleen E ; Koletar, Susan L ; Santana, Jorge ; Riddler, Sharon A ; Reichman, Richard ; Shikuma, Cecilia ; Meyer, William A ; Klingman, Karin L ; Gulick, Roy M ; ACTG A5166s Protocol Team2007 Apr 15J Infect Dis8195
Pre-existing minority drug-resistant HIV-1 variants, adherence, and risk of antiretroviral treatment failure.Paredes, Roger ; Lalama, Christina M ; Ribaudo, Heather J ; Schackman, Bruce R ; Shikuma, Cecilia ; Giguel, Francoise ; Meyer, William A ; Johnson, Victoria A ; Fiscus, Susan A ; D'Aquila, Richard T ; Gulick, Roy M ; Kuritzkes, Daniel R ; AIDS Clinical Trials Group (ACTG) A5095 Study Team2010 MarJ Infect Dis5201
Preexisting resistance to nonnucleoside reverse-transcriptase inhibitors predicts virologic failure of an efavirenz-based regimen in treatment-naive HIV-1-infected subjects.Kuritzkes, Daniel R ; Lalama, Christina M ; Ribaudo, Heather J ; Marcial, Michelle ; Meyer, William A ; Shikuma, Cecilia ; Johnson, Victoria A ; Fiscus, Susan A ; D'Aquila, Richard T ; Schackman, Bruce R ; Acosta, Edward P ; Gulick, Roy M2008 Mar 15J Infect Dis6197
A prospective, randomized clinical trial of antiretroviral therapies on carotid wall thickness.Stein, James H ; Ribaudo, Heather J ; Hodis, Howard N ; Brown, Todd T ; Tran, Thuy Tien T ; Yan, Mingzhu ; Brodell, Elizabeth Lauer ; Kelesidis, Theodore ; McComsey, Grace A ; Dubé, Michael P ; Murphy, Robert L ; Currier, Judith S2015 Sep 10AIDS1429
Racial differences in calculated bioavailable vitamin D with vitamin D/calcium supplementation.Yin, Michael T ; Chan, Ellen S ; Brown, Todd T ; Tebas, Pablo ; McComsey, Grace A ; Melbourne, Kathleen M ; Napoli, Andrew ; Hardin, William R ; Ribaudo, Heather J ; Overton, Edgar T ; A5280 Study Team2017 Nov 13AIDS1731
Racial differences in response to antiretroviral therapy for HIV infection: an AIDS clinical trials group (ACTG) study analysis.Ribaudo, Heather J ; Smith, Kimberly Y ; Robbins, Gregory K ; Flexner, Charles ; Haubrich, Richard ; Chen, Yun ; Fischl, Margaret A ; Schackman, Bruce R ; Riddler, Sharon A ; Gulick, Roy M2013 DecClin Infect Dis1157
Racial differences in virologic failure associated with adherence and quality of life on efavirenz-containing regimens for initial HIV therapy: results of ACTG A5095.Schackman, Bruce R ; Ribaudo, Heather J ; Krambrink, Amy ; Hughes, Valery ; Kuritzkes, Daniel R ; Gulick, Roy M2007 Dec 15J Acquir Immune Defic Syndr546
A Randomized, Double-Blinded, Placebo-Controlled Trial of Sitagliptin for Reducing Inflammation and Immune Activation in Treated and Suppressed HIV Infection.Dubé, Michael P ; Chan, Ellen S ; Lake, Jordan E ; Williams, Brett ; Kinslow, Jennifer ; Landay, Alan ; Coombs, Robert W ; Floris-Moore, Michelle ; Ribaudo, Heather J ; Yarasheski, Kevin E ; ACTG 5346 Team2018 Dec 10Clin Infect Dis
Relationship between minority nonnucleoside reverse transcriptase inhibitor resistance mutations, adherence, and the risk of virologic failure.Li, Jonathan Z ; Paredes, Roger ; Ribaudo, Heather J ; Svarovskaia, Evguenia S ; Kozal, Michael J ; Hullsiek, Katherine H ; Miller, Michael D ; Bangsberg, David R ; Kuritzkes, Daniel R2012 Jan 14AIDS226
Safety and Impact of Low-Dose Methotrexate on Endothelial Function and Inflammation in Individuals with Treated Human Immunodeficiency Virus: AIDS Clinical Trials Group Study A5314.Hsue, Priscilla Y ; Ribaudo, Heather J ; Deeks, Steven G ; Bell, Tanvir ; Ridker, Paul M ; Fichtenbaum, Carl ; Daar, Eric S ; Havlir, Diane ; Yeh, Eunice ; Tawakol, Ahmed ; Lederman, Michael ; Currier, Judith S ; Stein, James H2018 Sep 14Clin Infect Dis
Screening for UGT1A1 Genotype in Study A5257 Would Have Markedly Reduced Premature Discontinuation of Atazanavir for Hyperbilirubinemia.Vardhanabhuti, Saran ; Ribaudo, Heather J ; Landovitz, Raphael J ; Ofotokun, Ighovwerha ; Lennox, Jeffrey L ; Currier, Judith S ; Olson, Lana M ; Haas, David W2015 SepOpen Forum Infect Dis32
Substitution of nevirapine because of efavirenz toxicity in AIDS clinical trials group A5095.Schouten, Jeffrey T ; Krambrink, Amy ; Ribaudo, Heather J ; Kmack, Anne ; Webb, Nancy ; Shikuma, Cecilia ; Kuritzkes, Daniel R ; Gulick, Roy M2010 Mar 1Clin Infect Dis550
Three- vs four-drug antiretroviral regimens for the initial treatment of HIV-1 infection: a randomized controlled trial.Gulick, Roy M ; Ribaudo, Heather J ; Shikuma, Cecilia M ; Lalama, Christina ; Schackman, Bruce R ; Meyer, William A ; Acosta, Edward P ; Schouten, Jeffrey ; Squires, Kathleen E ; Pilcher, Christopher D ; Murphy, Robert L ; Koletar, Susan L ; Carlson, Margrit ; Reichman, Richard C ; Bastow, Barbara ; Klingman, Karin L ; Kuritzkes, Daniel R 2006 Aug 16JAMA7296
Ultrasonographic measures of cardiovascular disease risk in antiretroviral treatment-naive individuals with HIV infection.Stein, James H ; Brown, Todd T ; Ribaudo, Heather J ; Chen, Yun ; Yan, Mingzhu ; Lauer-Brodell, Elizabeth ; McComsey, Grace A ; Dubé, Michael P ; Murphy, Robert L ; Hodis, Howard N ; Currier, Judith S2013 Mar 27AIDS627
Vitamin D and Calcium Attenuate Bone Loss With Antiretroviral Therapy Initiation: A Randomized Trial.Overton, Edgar Turner ; Chan, Ellen S ; Brown, Todd T ; Tebas, Pablo ; McComsey, Grace A ; Melbourne, Kathleen M ; Napoli, Andrew ; Hardin, William Royce ; Ribaudo, Heather J ; Yin, Michael T2015 Jun 16Ann Intern Med12162