ACTG Publications

Pharmacokinetic/pharmacodynamic modeling of the antiretroviral activity of the CCR5 antagonist Vicriviroc in treatment experienced HIV-infected subjects (ACTG protocol 5211).Crawford, Keith W ; Li, Chonghua ; Keung, Anther ; Su, Zhaohui ; Hughes, Michael D ; Greaves, Wayne ; Kuritzkes, Daniel ; Gulick, Roy ; Flexner, Charles ; ACTG A5211 Study Team2010 AprJ Acquir Immune Defic Syndr553
Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211.Gulick, Roy M ; Su, Zhaohui ; Flexner, Charles ; Hughes, Michael D ; Skolnik, Paul R ; Wilkin, Timothy J ; Gross, Robert ; Krambrink, Amy ; Coakley, Eoin ; Greaves, Wayne L ; Zolopa, Andrew ; Reichman, Richard ; Godfrey, Catherine ; Hirsch, Martin ; Kuritzkes, Daniel R ; AIDS Clinical Trials Group 5211 Team2007 Jul 15J Infect Dis2196
Detection of nonnucleoside reverse-transcriptase inhibitor-resistant HIV-1 after discontinuation of virologically suppressive antiretroviral therapy.Hare, C Bradley ; Mellors, John ; Krambrink, Amy ; Su, Zhaohui ; Skiest, Daniel ; Margolis, David M ; Patel, Sheran S ; Barnas, Douglas ; Frenkel, Lisa ; Coombs, Robert W ; Aweeka, Francesca ; Morse, Gene D ; Haas, David W ; Boltz, Valerie ; Palmer, Sarah ; Coffin, John ; Havlir, Diane V2008 Aug 1Clin Infect Dis347
Assessing human immunodeficiency virus type 1 tropism: Comparison of assays using replication-competent virus versus plasma-derived pseudotyped virions.Hosoya, Noriaki ; Su, Zhaohui ; Wilkin, Timothy ; Gulick, Roy M ; Flexner, Charles ; Hughes, Michael D ; Skolnik, Paul R ; Giguel, Francoise ; Greaves, Wayne L ; Coakley, Eoin ; Kuritzkes, Daniel R2009 AugJ Clin Microbiol847
Uridine supplementation in the treatment of HIV lipoatrophy: results of ACTG 5229.McComsey, Grace A ; Walker, Ulrich A ; Budhathoki, Chakra B ; Su, Zhaohui ; Currier, Judith S ; Kosmiski, Lisa ; Naini, Linda G ; Charles, St├ęphannie ; Medvik, Kathy ; Aberg, Judith A ; AIDS Clinical Trials Group A5229 Team2010 Oct 23AIDS1624
Association of HIV neutralizing antibody with lower viral load after treatment interruption in a prospective trial (A5170).McLinden, Robert J ; Paris, Robert M ; Polonis, Victoria R ; Close, Nicole C ; Su, Zhaohui ; Shikuma, Cecilia M ; Margolis, David M ; Kim, Jerome H2012 Jan 2AIDS126
Improved measures of quality of life, lipid profile, and lipoatrophy after treatment interruption in HIV-infected patients with immune preservation: results of ACTG 5170.Skiest, Daniel J ; Krambrink, Amy ; Su, Zhaohui ; Robertson, Kevin R ; Margolis, David M ; A5170 Study Team2008 Dec 1J Acquir Immune Defic Syndr449
Interruption of antiretroviral treatment in HIV-infected patients with preserved immune function is associated with a low rate of clinical progression: a prospective study by AIDS Clinical Trials Group 5170.Skiest, Daniel J ; Su, Zhaohui ; Havlir, Diane V ; Robertson, Kevin R ; Coombs, Robert W ; Cain, Pat ; Peterson, Tianna ; Krambrink, Amy ; Jahed, Nasreen ; McMahon, Deborah ; Margolis, David M ; AIDS Clinical Trials Group 5170 Study Team2007 May 15J Infect Dis10195
Response to vicriviroc in treatment-experienced subjects, as determined by an enhanced-sensitivity coreceptor tropism assay: reanalysis of AIDS clinical trials group A5211.Su, Zhaohui ; Gulick, Roy M ; Krambrink, Amy ; Coakley, Eoin ; Hughes, Michael D ; Han, Dong ; Flexner, Charles ; Wilkin, Timothy J ; Skolnik, Paul R ; Greaves, Wayne L ; Kuritzkes, Daniel R ; Reeves, Jacqueline D ; AIDS Clinical Trials Group A5211 Team2009 Dec 1J Infect Dis11200
Vicriviroc resistance decay and relative replicative fitness in HIV-1 clinical isolates under sequential drug selection pressures.Tsibris, Athe M N ; Hu, Zixin ; Paredes, Roger ; Leopold, Kay E ; Putcharoen, Opass ; Schure, Allison L ; Mazur, Natalie ; Coakley, Eoin ; Su, Zhaohui ; Gulick, Roy M ; Kuritzkes, Daniel R2012 JunJ Virol1286
Quantitative deep sequencing reveals dynamic HIV-1 escape and large population shifts during CCR5 antagonist therapy in vivo.Tsibris, Athe M N ; Korber, Bette ; Arnaout, Ramy ; Russ, Carsten ; Lo, Chien-Chi ; Leitner, Thomas ; Gaschen, Brian ; Theiler, James ; Paredes, Roger ; Su, Zhaohui ; Hughes, Michael D ; Gulick, Roy M ; Greaves, Wayne ; Coakley, Eoin ; Flexner, Charles ; Nusbaum, Chad ; Kuritzkes, Daniel R2009PLoS One54
Lymphoma diagnosis and plasma Epstein-Barr virus load during vicriviroc therapy: results of the AIDS Clinical Trials Group A5211.Tsibris, Athe M N ; Paredes, Roger ; Chadburn, Amy ; Su, Zhaohui ; Henrich, Timothy J ; Krambrink, Amy ; Hughes, Michael D ; Aberg, Judith A ; Currier, Judith S ; Tashima, Karen ; Godfrey, Catherine ; Greaves, Wayne ; Flexner, Charles ; Skolnik, Paul R ; Wilkin, Timothy J ; Gulick, Roy M ; Kuritzkes, Daniel R2009 Mar 1Clin Infect Dis548
In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject.Tsibris, Athe M N ; Sagar, Manish ; Gulick, Roy M ; Su, Zhaohui ; Hughes, Michael ; Greaves, Wayne ; Subramanian, Mani ; Flexner, Charles ; Giguel, Francoise ; Leopold, Kay E ; Coakley, Eoin ; Kuritzkes, Daniel R2008 AugJ Virol1682
CD4+ T-cell decline after the interruption of antiretroviral therapy in ACTG A5170 is predicted by differential expression of genes in the ras signaling pathway.Vahey, Maryanne T ; Wang, Zhining ; Su, Zhaohui ; Nau, Martin E ; Krambrink, Amy ; Skiest, Daniel J ; Margolis, David M2008 AugAIDS Res Hum Retroviruses824
Reanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity.Wilkin, Timothy J ; Goetz, Mathew Bidwell ; Leduc, Robert ; Skowron, Gail ; Su, Zhaohui ; Chan, Ellen S ; Heera, Jayyant ; Chapman, Doug ; Spritzler, John ; Reeves, Jacqueline D ; Gulick, Roy M ; Coakley, Eoin2011 Apr 1Clin Infect Dis752
Three-year safety and efficacy of vicriviroc, a CCR5 antagonist, in HIV-1-infected treatment-experienced patients.Wilkin, Timothy J ; Su, Zhaohui ; Krambrink, Amy ; Long, Jianmin ; Greaves, Wayne ; Gross, Robert ; Hughes, Michael D ; Flexner, Charles ; Skolnik, Paul R ; Coakley, Eoin ; Godfrey, Catherine ; Hirsch, Martin ; Kuritzkes, Daniel R ; Gulick, Roy M2010 AugJ Acquir Immune Defic Syndr554