Antiretroviral concentrations in hair strongly predict virologic response in a large HIV treatment-naive clinical trial.

TitleAntiretroviral concentrations in hair strongly predict virologic response in a large HIV treatment-naive clinical trial.
Publication TypeJournal Article
Year of Publication2018
AuthorsGandhi M, Ofokotun I, Bacchetti P, Jin C, Ribaudo HJ, Haas DW, Sheth AN, Horng H, Phung N, Kuncze K, Okochi H, Landovitz RJ, Lennox J, Currier JS
Corporate AuthorsAIDS Clinical Trials Group(ACTG) 5257 study team
JournalClin Infect Dis
Date Published2018 Sep 03
ISSN1537-6591
Abstract

Hair concentrations of antiretrovirals are associated with virologic outcomes in cohorts of HIV-positive individuals but have never before been examined in a clinical trial. We show for the first time the predictive utility of hair antiretroviral concentrations in a large HIV treatment-naïve trial, AIDS Clinical Trials Group (ACTG) protocol A5257.

DOI10.1093/cid/ciy764
Alternate JournalClin. Infect. Dis.
PubMed ID30184104
Grant ListUM1 AI068634 / AI / NIAID NIH HHS / United States
R21 AI112362 / AI / NIAID NIH HHS / United States
UM1 AI106701 / AI / NIAID NIH HHS / United States
R01 AI098472 / AI / NIAID NIH HHS / United States
U01 AI068634 / AI / NIAID NIH HHS / United States
UM1 AI068636 / AI / NIAID NIH HHS / United States