Similar changes in neuropsychological functioning in english and spanish speaking HIV patients.

TitleSimilar changes in neuropsychological functioning in english and spanish speaking HIV patients.
Publication TypeJournal Article
Year of Publication2018
AuthorsAkpa O, Miyahara S, Taiwo B, Evans S, Berzins B, Robertson K
JournalBrain Behav
Volume8
Issue9
Paginatione01083
Date Published2018 Sep
ISSN2162-3279
Abstract

OBJECTIVE: Primary language has been reported to influence the results of neuropsychological (NP) testing. We sought to determine whether being a primary Spanish versus English speaker affects changes in neuropsychological evaluations in persons living with HIV.

METHOD: Data from 209 (188 English speakers and 21 Spanish speakers) ART-naïve HIV-infected adults were extracted from ACTG A5303, a 48-week randomized clinical trial of two HIV treatment regimens. Participants' mean (standard deviation) age and years of education were 35.1 (10.7) and 14.3 (2.7) years respectively. Changes from baseline to week 48 of antiretroviral therapy (ART) in individual, total, and domain z-scores for NP tests and Global Deficit Scores (GDS) were compared between the primary languages using linear regression models, adjusted for baseline scores and years of education.

RESULTS: Baseline demographic characteristics were comparable except Spanish speakers had less years of education than the English speakers (p < 0.001). Although differences in some NP measures and domains were detected at baseline, the adjusted changes in individual, total and domain NPz-scores from baseline to 48 weeks of ART were not significantly different between the two primary language groups. The 48-week changes in GDS were also similar.

CONCLUSION: Changes in NP during ART were similar between English and Spanish speaking HIV-infected individuals for all NP measures. This suggests that studies of longitudinal changes in NP can pool participants across these languages.

DOI10.1002/brb3.1083
Alternate JournalBrain Behav
PubMed ID30047258
PubMed Central IDPMC6160655
Grant ListUL1 RR025780 / GF / NIH HHS / United States
UM1 AI069423 / AI / NIAID NIH HHS / United States
UM1AI 069471 / GF / NIH HHS / United States
UM1 AI069496 / GF / NIH HHS / United States
2UM1AI069418-08 / GF / NIH HHS / United States
2UMAI069432 / GF / NIH HHS / United States
UM1 AI069471 / GF / NIH HHS / United States
UM1 AI069465 / GF / NIH HHS / United States
P30 AI50410 / GF / NIH HHS / United States
2UMIA1069423-08 / GF / NIH HHS / United States
UL1 RR024160 / GF / NIH HHS / United States
UL1TR001079 / GF / NIH HHS / United States
2UM1AI069432 / GF / NIH HHS / United States
U01AI068636 / / National Institute of Allergy and Infectious Diseases and supported by National Institute of Mental Health (NIMH), National Institute of Dental and Craniofacial Research (NIDCR) /
D43TW009608 / / Fogarty International Center and National Institute of Mental Health of the National Institutes of Health /
UL1TR000454 / GF / NIH HHS / United States
UM1 AI069471 / AI / NIAID NIH HHS / United States
UL1 TR002535 / TR / NCATS NIH HHS / United States
/ / National Center for Advancing Translational Sciences/NIH /
2UM1AI069412-08 / GF / NIH HHS / United States
UL1 TR000042 / GF / NIH HHS / United States
5UM1AI069412 / GF / NIH HHS / United States
NO1-HD-3-3345 / GF / NIH HHS / United States
UL1 TR001082 / GF / NIH HHS / United States
5UM1 AI068636 / GF / NIH HHS / United States
UMI AI069511 / GF / NIH HHS / United States
UM1AI069472 / GF / NIH HHS / United States
U01AI069447 / GF / NIH HHS / United States
UM1 AI068634 / AI / NIAID NIH HHS / United States
2UM1-AI069470-08 / GF / NIH HHS / United States
UMAI069432 / GF / NIH HHS / United States
AI068636 / GF / NIH HHS / United States
1UL1TR001111 / GF / NIH HHS / United States
UMAI069494 / GF / NIH HHS / United States
2UM1AI069503 / GF / NIH HHS / United States
UM1 AI069423 / GF / NIH HHS / United States
2UM1AI069439-08 / GF / NIH HHS / United States
P30AI073961 / GF / NIH HHS / United States
D43 TW009608 / TW / FIC NIH HHS / United States
5 P30 AI-045008-15 / GF / NIH HHS / United States
2P30 AI 50409-10 / GF / NIH HHS / United States
UL1 TR000445 / GF / NIH HHS / United States
UM1AI069471 / GF / NIH HHS / United States
UM1 AI106701 / AI / NIAID NIH HHS / United States
UM1 AI069501 / GF / NIH HHS / United States
AI069501 / GF / NIH HHS / United States
5UM1AI069415-10 / GF / NIH HHS / United States
UM1A 068636-09 / GF / NIH HHS / United States
AI069424 / GF / NIH HHS / United States
UM1AI069452 / GF / NIH HHS / United States
AI 69501 / GF / NIH HHS / United States
AI068634 / GF / NIH HHS / United States
AI69439 / GF / NIH HHS / United States
U01 AI068634 / AI / NIAID NIH HHS / United States
UM1 AI068636 / AI / NIAID NIH HHS / United States
1U01AI069477-01 / GF / NIH HHS / United States