Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine.

TitleEffect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine.
Publication TypeJournal Article
Year of Publication2018
AuthorsIppolito MM, Jacobson JM, Lederman MM, Winterberg M, Tarning J, Shapiro TA, Flexner C
JournalClin Infect Dis
Volume67
Issue10
Pagination1617-1620
Date Published2018 Oct 30
ISSN1537-6591
Abstract

The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor-based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.

DOI10.1093/cid/ciy405
Alternate JournalClin. Infect. Dis.
PubMed ID29771277
PubMed Central IDPMC6206114
Grant ListT32 GM066691 / GM / NIGMS NIH HHS / United States
UM1 AI069501 / AI / NIAID NIH HHS / United States