Quality of life among HIV-infected individuals failing first-line antiretroviral therapy in resource-limited settings.

TitleQuality of life among HIV-infected individuals failing first-line antiretroviral therapy in resource-limited settings.
Publication TypeJournal Article
Year of Publication2018
AuthorsTorres TS, Harrison LJ, La Rosa AM, Lavenberg JA, Zheng L, Safren SA, Ngongondo MN, Poongulali S, Matoga M, Samaneka W, Collier AC, Hughes MD
JournalAIDS Care
Volume30
Issue8
Pagination954-962
Date Published2018 Aug
ISSN1360-0451
Abstract

We evaluated health-related quality of life (QoL) in HIV infection participants with virologic failure (VF) on first-line antiretroviral therapy (ART) in 9 resource-limited settings (RLS). ACTG SF-21 was completed by 512 participants at A5273 study entry; 8 domains assessed: general health perceptions (GHP), physical functioning (PF), role functioning (RF), social functioning (SF), cognitive functioning (CF), pain (P), mental health (MH), and energy/fatigue (E/F); each was scored between 0 (worst) to 100 (best). Mean QoL scores ranged from 67 (GHP) to 91 (PF, SF, CF). QoL varied by country; high VL and low CD4 were associated with worse QoL in most domains, except RF (VL only), SF (CD4 only) and CF (neither). Number of comorbidities, BMI and history of AIDS were associated with some domains. Relationships between QoL and VL varied among countries for all domains. The association of worse disease status with worse QoL may reflect low QoL when ART was initiated and/or deterioration associated with VF.

DOI10.1080/09540121.2018.1427207
Alternate JournalAIDS Care
PubMed ID29343078
PubMed Central IDPMC6100767
Grant ListUM1 AI069423 / AI / NIAID NIH HHS / United States
U01 AI069438 / AI / NIAID NIH HHS / United States
UM1 AI069476 / AI / NIAID NIH HHS / United States
UM1 AI069432 / AI / NIAID NIH HHS / United States
UM1 AI069412 / AI / NIAID NIH HHS / United States
UM1 AI068634 / AI / NIAID NIH HHS / United States
UM1 AI069481 / AI / NIAID NIH HHS / United States
U01 AI069432 / AI / NIAID NIH HHS / United States
U01 AI068636 / AI / NIAID NIH HHS / United States
P30 AI027757 / AI / NIAID NIH HHS / United States
UM1 AI069436 / AI / NIAID NIH HHS / United States
UM1 AI068636 / AI / NIAID NIH HHS / United States