Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome.

TitleAssociations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome.
Publication TypeJournal Article
Year of Publication2017
AuthorsGeorge V, Harrison L, Roach M, Li X-D, Tierney C, Fischl MA, Aberg J, Tebas P, Asmuth DM, Pollard RB, Godfrey C, Pahwa S
Corporate AuthorsAIDS Clinical Trials Group A5202 Study Team
JournalJ Infect Dis
Volume216
Issue9
Pagination1159-1163
Date Published2017 Nov 27
ISSN1537-6613
KeywordsAnti-HIV Agents, Biomarkers, Cohort Studies, Cytokines, HIV Infections, Humans, Immune Reconstitution Inflammatory Syndrome, Translocation, Genetic
Abstract

A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.

DOI10.1093/infdis/jix460
Alternate JournalJ. Infect. Dis.
PubMed ID29040604