Association Between Frailty and Components of the Frailty Phenotype With Modifiable Risk Factors and Antiretroviral Therapy.

TitleAssociation Between Frailty and Components of the Frailty Phenotype With Modifiable Risk Factors and Antiretroviral Therapy.
Publication TypeJournal Article
Year of Publication2017
AuthorsErlandson KM, Wu K, Koletar SL, Kalayjian RC, Ellis RJ, Taiwo B, Palella FJ, Tassiopoulos K
JournalJ Infect Dis
Volume215
Issue6
Pagination933-937
Date Published2017 03 15
ISSN1537-6613
KeywordsAged, Aged, 80 and over, Antiretroviral Therapy, Highly Active, Female, Frail Elderly, HIV Infections, Humans, Logistic Models, Male, Middle Aged, Phenotype, Risk Factors, United States, Walking Speed, Weight Loss
Abstract

The impact of antiretroviral therapy (ART) on frailty among human immunodeficiency virus (HIV)-infected adults has not been well described. HIV-infected participants aged ≥40 years with initial ART receipt through a randomized, controlled AIDS Clinical Trials Group trial completed a frailty assessment. Ordinal logistic regression models examined factors associated with frailty. Of 1016 participants, 6% were frail, and 38% were prefrail. Frailty was associated with lower education, older age, Medicare/Medicaid, initial efavirenz, smoking, obesity, and neurocognitive impairment; physical activity and alcohol use were protective. The associations with ART require further investigation, and associations between frailty and modifiable factors provide targets for future interventions.

DOI10.1093/infdis/jix063
Alternate JournalJ. Infect. Dis.
PubMed ID28453849
PubMed Central IDPMC5407051
Grant ListUM1 AI069494 / AI / NIAID NIH HHS / United States
K23 AG050260 / AG / NIA NIH HHS / United States
UM1 AI069471 / AI / NIAID NIH HHS / United States
R01 AG054366 / AG / NIA NIH HHS / United States
UM1 AI068634 / AI / NIAID NIH HHS / United States
P30 MH062512 / MH / NIMH NIH HHS / United States
UM1 AI106701 / AI / NIAID NIH HHS / United States
U01 AI035039 / AI / NIAID NIH HHS / United States
UM1 AI068636 / AI / NIAID NIH HHS / United States