A survey of tuberculosis infection control practices at the NIH/NIAID/DAIDS-supported clinical trial sites in low and middle income countries.

TitleA survey of tuberculosis infection control practices at the NIH/NIAID/DAIDS-supported clinical trial sites in low and middle income countries.
Publication TypeJournal Article
Year of Publication2016
AuthorsGodfrey C, Tauscher G, Hunsberger S, Austin M, Scott L, Schouten JT, Luetkemeyer AF, Benson C, Coombs R, Swindells S
Corporate AuthorsHIV Network Coordinating(HANC) TB Diagnostic Laboratory Working Division of AIDS, National Institute of Allergy and Infectious Diseases
JournalBMC Infect Dis
Volume16
Pagination269
Date Published2016 06 10
ISSN1471-2334
KeywordsClinical Trials as Topic, Developing Countries, Facility Design and Construction, Guideline Adherence, Hand Disinfection, Health Personnel, Humans, Infection Control, Infectious Disease Transmission, Patient-to-Professional, Masks, Mass Screening, Mycobacterium tuberculosis, National Institute of Allergy and Infectious Diseases (U.S.), Practice Guidelines as Topic, Surveys and Questionnaires, Tuberculosis, United States, Ventilation
Abstract

BACKGROUND: Health care associated transmission of Mycobacterium tuberculosis (TB) is well described. A previous survey of infection control (IC) practices at clinical research sites in low and middle income countries (LMIC) funded by the National Institute of Allergy and Infectious Diseases (NIAID) conducting HIV research identified issues with respiratory IC practices. A guideline for TB IC based on international recommendations was developed and promulgated. This paper reports on adherence to the guideline at sites conducting or planning to conduct TB studies with the intention of supporting improvement.

METHODS: A survey was developed that assessed IC activities in three domains: facility level measures, administrative control measures and environmental measures. An external site monitor visited each site in 2013-2014, to complete the audit. A central review committee evaluated the site-level survey and results were tabulated. Fisher's exact test was performed to determine whether there were significant differences in practices at sites that had IC officers versus sites that did not have IC officers. Significance was assessed at p

DOI10.1186/s12879-016-1579-y
Alternate JournalBMC Infect. Dis.
PubMed ID27287374
PubMed Central IDPMC4901412
Grant ListUM1 AI068636 / AI / NIAID NIH HHS / United States
UM1 AI069496 / AI / NIAID NIH HHS / United States
UM1 AI106701 / AI / NIAID NIH HHS / United States