Diversity and Tropism of HIV-1 Rebound Virus Populations in Plasma Level After Treatment Discontinuation.

TitleDiversity and Tropism of HIV-1 Rebound Virus Populations in Plasma Level After Treatment Discontinuation.
Publication TypeJournal Article
Year of Publication2016
AuthorsBednar MM, Hauser BM, Zhou S, Jacobson JM, Eron JJ, Frank I, Swanstrom R
JournalJ Infect Dis
Volume214
Issue3
Pagination403-7
Date Published2016 Aug 01
ISSN1537-6613
Abstract

Human immunodeficiency virus-infected people discontinuing therapy experience a rebound in the virus level (hereafter, "rebound virus") from a persistent reservoir. We examined 10 samples from patients in AIDS Clinical Trials Group study A5068 with rebound virus, using single-genome amplification and Primer ID deep sequencing, to assess env genetic diversity of the virus population. Most rebound-virus populations showed significant diversity. All env examined required high levels of CD4 for entry, consistent with selection of replication in CD4(+) T cells. These results indicate that most people discontinuing therapy release a diverse population of virus and that this released virus has entry features of virus selected for replication in CD4(+) T cells, rather than in myeloid cells.

DOI10.1093/infdis/jiw172
Alternate JournalJ. Infect. Dis.
PubMed ID27132284
PubMed Central IDPMC4936648
Grant ListUM1 AI068634 / AI / NIAID NIH HHS / United States
UM1 AI068636 / AI / NIAID NIH HHS / United States
UM1 AI106701 / AI / NIAID NIH HHS / United States