Title | Diversity and Tropism of HIV-1 Rebound Virus Populations in Plasma Level After Treatment Discontinuation. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Bednar MM, Hauser BM, Zhou S, Jacobson JM, Eron JJ, Frank I, Swanstrom R |
Journal | J Infect Dis |
Volume | 214 |
Issue | 3 |
Pagination | 403-7 |
Date Published | 2016 Aug 01 |
ISSN | 1537-6613 |
Abstract | Human immunodeficiency virus-infected people discontinuing therapy experience a rebound in the virus level (hereafter, "rebound virus") from a persistent reservoir. We examined 10 samples from patients in AIDS Clinical Trials Group study A5068 with rebound virus, using single-genome amplification and Primer ID deep sequencing, to assess env genetic diversity of the virus population. Most rebound-virus populations showed significant diversity. All env examined required high levels of CD4 for entry, consistent with selection of replication in CD4(+) T cells. These results indicate that most people discontinuing therapy release a diverse population of virus and that this released virus has entry features of virus selected for replication in CD4(+) T cells, rather than in myeloid cells. |
DOI | 10.1093/infdis/jiw172 |
Alternate Journal | J. Infect. Dis. |
PubMed ID | 27132284 |
PubMed Central ID | PMC4936648 |
Grant List | UM1 AI068634 / AI / NIAID NIH HHS / United States UM1 AI068636 / AI / NIAID NIH HHS / United States UM1 AI106701 / AI / NIAID NIH HHS / United States |