Brief Report: Relationship Among Viral Load Outcomes in HIV Treatment Interruption Trials.

TitleBrief Report: Relationship Among Viral Load Outcomes in HIV Treatment Interruption Trials.
Publication TypeJournal Article
Year of Publication2016
AuthorsTreasure GC, Aga E, Bosch RJ, Mellors JW, Kuritzkes DR, Para M, Gandhi RT, Li JZ
JournalJ Acquir Immune Defic Syndr
Volume72
Issue3
Pagination310-3
Date Published2016 Jul 1
ISSN1944-7884
Abstract

Viral load (VL) rebound timing and set point were analyzed in 235 participants undergoing analytic treatment interruption (ATI) in 6 AIDS Clinical Trials Group studies. There was no significant association between rebound timing and ATI VL set point for those who rebounded ≤12 weeks. VL set points were lower in participants with rebound >12 weeks (P < 0.001) and participants treated during early infection (P < 0.001). Pre-antiretroviral therapy VL correlated with set point, though 68% of participants had a set point lower than pre-antiretroviral therapy VL. These results illustrate complex relationships between post-ATI virologic outcomes and the potential presence of biological factors mediating rebound timing and set point.

DOI10.1097/QAI.0000000000000964
Alternate JournalJ. Acquir. Immune Defic. Syndr.
PubMed ID26910502
PubMed Central IDPMC4911279
Grant ListK08 AI100699 / AI / NIAID NIH HHS / United States
UM1 AI068634 / AI / NIAID NIH HHS / United States
UM1 AI068636 / AI / NIAID NIH HHS / United States