Long-term Bone Mineral Density Changes in Antiretroviral-Treated HIV-Infected Individuals.

TitleLong-term Bone Mineral Density Changes in Antiretroviral-Treated HIV-Infected Individuals.
Publication TypeJournal Article
Year of Publication2016
AuthorsGrant PM, Kitch D, McComsey GA, Collier AC, Koletar SL, Erlandson KM, Yin MT, Bartali B, Ha B, Melbourne K, Brown TT
JournalJ Infect Dis
Volume214
Issue4
Pagination607-11
Date Published2016 Aug 15
ISSN1537-6613
Abstract

We compared adjusted bone mineral density (BMD) changes between human immunodeficiency virus (HIV)-infected individuals during the first approximately 7.5 years after antiretroviral therapy (ART) initiation and HIV-uninfected controls. HIV-infected individuals (n = 97) had significantly greater adjusted BMD decline than controls (n = 614) during the first 96 weeks of ART. Subsequently, the rate of BMD decline slowed in HIV-infected individuals but remained greater than the rate of decline in HIV-uninfected individuals at the lumbar spine but not at the hip. In HIV-infected individuals after 96 weeks, no HIV- or treatment-related characteristic was associated with BMD loss, but lower lean body mass was associated with greater BMD loss at both lumbar spine and hip.

DOI10.1093/infdis/jiw204
Alternate JournalJ. Infect. Dis.
PubMed ID27330053
PubMed Central IDPMC4957444
Grant ListK23 AG050260 / AG / NIA NIH HHS / United States