Title | Long-term Bone Mineral Density Changes in Antiretroviral-Treated HIV-Infected Individuals. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Grant PM, Kitch D, McComsey GA, Collier AC, Koletar SL, Erlandson KM, Yin MT, Bartali B, Ha B, Melbourne K, Brown TT |
Journal | J Infect Dis |
Volume | 214 |
Issue | 4 |
Pagination | 607-11 |
Date Published | 2016 Aug 15 |
ISSN | 1537-6613 |
Abstract | We compared adjusted bone mineral density (BMD) changes between human immunodeficiency virus (HIV)-infected individuals during the first approximately 7.5 years after antiretroviral therapy (ART) initiation and HIV-uninfected controls. HIV-infected individuals (n = 97) had significantly greater adjusted BMD decline than controls (n = 614) during the first 96 weeks of ART. Subsequently, the rate of BMD decline slowed in HIV-infected individuals but remained greater than the rate of decline in HIV-uninfected individuals at the lumbar spine but not at the hip. In HIV-infected individuals after 96 weeks, no HIV- or treatment-related characteristic was associated with BMD loss, but lower lean body mass was associated with greater BMD loss at both lumbar spine and hip. |
DOI | 10.1093/infdis/jiw204 |
Alternate Journal | J. Infect. Dis. |
PubMed ID | 27330053 |
PubMed Central ID | PMC4957444 |
Grant List | K23 AG050260 / AG / NIA NIH HHS / United States |