IL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease.

TitleIL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease.
Publication TypeJournal Article
Year of Publication2009
AuthorsPrice P, James I
JournalAIDS
Volume23
Issue9
Pagination1173-6
Date Published2009 Jun 1
ISSN1473-5571
KeywordsAntiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Female, Genetic Linkage, HIV Infections, HIV-1, Humans, Interleukin-1alpha, Male, RNA, Viral
Abstract

Among Australians treated for advanced HIV disease, a suboptimal virological response was associated with allele 2 at interleukin 1 alpha (IL1A)-889 and IL1A+4845. This is confirmed and investigated using patients from AIDS Clinical Trials Group study 384 (n=532). Among non-African-American patients with CD4 T-cell count of< or = 100 cells/microl at baseline, IL1A+4845(*)TT was associated with poor virological outcome (P=0.03). Differences were smaller with higher baseline CD4 T-cell counts. IL1A-889 and IL1A+4845 were not in linkage disequilibrium in African-American patients, and IL1A+4845(*)T did not affect outcome.

Alternate JournalAIDS
PubMed ID19462524
Grant ListAI068636 / AI / NIAID NIH HHS / United States
RR024975 / RR / NCRR NIH HHS / United States