Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection.

TitleHerpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection.
Publication TypeJournal Article
Year of Publication2007
AuthorsCachay ER, Frost SDW, Richman DD, Smith DM, Little SJ
JournalJ Infect Dis
Volume195
Issue9
Pagination1270-7
Date Published2007 May 1
ISSN0022-1899
KeywordsAdult, California, Cohort Studies, Herpes Simplex, Herpesvirus 2, Human, HIV Infections, HIV-1, Humans, Longitudinal Studies, Male, Prevalence, Retrospective Studies, Viral Load
Abstract

OBJECTIVE: We sought to compare baseline and longitudinal plasma HIV-1 loads between herpes simplex virus type 2 (HSV-2)-seropositive and -seronegative individuals who are enrolled in a primary HIV-1 infection cohort in San Diego, California.

DESIGN: The study was a retrospective cohort analysis.

METHODS: We categorized antiretroviral-naive subjects on the basis of HSV-2 serostatus at baseline using an HSV-2 enzyme immunoassay. Low positive results (1.1-3.5) were confirmed by Western blotting. We compared baseline HIV-1 loads of the 2 groups using a linear model. To detect differences in HIV-1 dynamics, we analyzed longitudinal viral loads using a flexible semiparametric model, controlling for the time to antiretroviral therapy and stratifying by HIV-1 infection stage at entry.

RESULTS: We studied 294 adult men. Ninety percent reported sex with men as their main HIV-1 risk factor. The seroprevalence of HSV-2 was 41.5%. The HSV-2-seropositive and -seronegative groups had similar baseline HIV-1 loads during acute infection (5.52 vs. 5.72 log(10) copies/mL; P=.39) and early infection (4.57 vs. 4.67 log(10) copies/mL; P=.5). Longitudinally, the difference in HIV-1 loads between HSV-2-seropositive and -seronegative men remained close to 0 during the first year of infection.

CONCLUSIONS: HSV-2 serostatus has minimal influence on the dynamics of HIV-1 during acute and early HIV-1 infection.

DOI10.1086/513568
Alternate JournalJ. Infect. Dis.
PubMed ID17396995
Grant List5K23 AI55276 / AI / NIAID NIH HHS / United States
AI27670 / AI / NIAID NIH HHS / United States
AI29164 / AI / NIAID NIH HHS / United States
AI36214 / AI / NIAID NIH HHS / United States
AI43638 / AI / NIAID NIH HHS / United States
AI47745 / AI / NIAID NIH HHS / United States
AI57167 / AI / NIAID NIH HHS / United States