HIV drug development: the next 25 years.

TitleHIV drug development: the next 25 years.
Publication TypeJournal Article
Year of Publication2007
AuthorsFlexner C
JournalNat Rev Drug Discov
Volume6
Issue12
Pagination959-66
Date Published2007 Dec
ISSN1474-1784
KeywordsAcquired Immunodeficiency Syndrome, Anti-HIV Agents, Drugs, Investigational, Humans, Pharmaceutical Preparations
Abstract

The development of drugs for HIV infection began soon after the virus was discovered 25 years ago. Since then, progress has been substantial, but numerous uncertainties persist about the best way to manage this disease. Here we review the current treatment options, consider novel mechanisms that can be exploited for existing drug targets, and explore the potential of novel targets. With a view to the next quarter century, we consider whether drug resistance can be avoided, which drug classes will be favoured over others, which strategies are most likely to succeed, and the potential impact of pharmacogenomics and individualized therapy.

DOI10.1038/nrd2336
Alternate JournalNat Rev Drug Discov
PubMed ID17932493
Grant ListAI-068636 / AI / NIAID NIH HHS / United States
AI-069465 / AI / NIAID NIH HHS / United States
AI-27668 / AI / NIAID NIH HHS / United States