Viral factors associated with cytokine expression during HCV/HIV co-infection.

TitleViral factors associated with cytokine expression during HCV/HIV co-infection.
Publication TypeJournal Article
Year of Publication2007
AuthorsBlackard JT, Kang M, J St Clair B, Lin W, Kamegaya Y, Sherman KE, Koziel MJames, Peters MG, Andersen J, Chung RT
Corporate AuthorsAids Clinical Trials Group A5071 Study Team
JournalJ Interferon Cytokine Res
Date Published2007 Apr
KeywordsAdult, Comorbidity, Cytokines, Female, Hepatitis C, HIV Infections, Humans, Male, Middle Aged, Regression Analysis, Transforming Growth Factor beta1, Tumor Necrosis Factor-alpha, Viruses

Co-infection with human immunodeficiency virus (HIV) is associated with reduced hepatitis C virus (HCV) treatment response and accelerated HCV disease. Cytokines, as mediators of immune responses, inflammation, and fibrogenesis, may underlie important differences in HCV pathogenesis during HIV co-infection. We previously found that serum interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) increased after HCV therapy with interferon (IFN) in HCV/HIV co-infected patients; however, cytokine levels were not predictive of HCV therapeutic response. Here, we examined viral factors associated with expression of IL-8, TNF-alpha, and transforming growth factor-beta1 (TGF-beta1) in uninfected, HCV mono-infected, HIV mono-infected, and HCV/HIV co-infected persons. HIV co-infection was associated with decreased IL-8 detection but not TNF-alpha detection. A significant interaction effect demonstrated that HIV infection was associated with elevated TGF-beta1 in HCV-positive individuals but not in HCV-negative individuals. The induction of a sustained profibrotic signal, such as TGF-beta1, by HIV may cause accelerated liver fibrosis during HCV/HIV co-infection and may hinder the host's ability to mount an effective HCV-specific immune response. Further studies are warranted to identify noninvasive markers of liver disease for the clinical management of HCV disease, particularly when liver biopsies have not been performed or are contraindicated.

Alternate JournalJ. Interferon Cytokine Res.
PubMed ID17477814
PubMed Central IDPMC4066618
Grant ListAI38855 / AI / NIAID NIH HHS / United States
AI38858 / AI / NIAID NIH HHS / United States
P30-AI42851 / AI / NIAID NIH HHS / United States
U01 AI069502 / AI / NIAID NIH HHS / United States