Comparative efficacy of nucleoside/nucleotide reverse transcriptase inhibitors in combination with efavirenz: results of a systematic overview.

TitleComparative efficacy of nucleoside/nucleotide reverse transcriptase inhibitors in combination with efavirenz: results of a systematic overview.
Publication TypeJournal Article
Year of Publication2007
AuthorsBartlett JA, Chen S-S, Quinn JB
JournalHIV Clin Trials
Volume8
Issue4
Pagination221-6
Date Published2007 Jul-Aug
ISSN1528-4336
KeywordsAdenine, Adult, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Benzoxazines, CD4 Lymphocyte Count, Female, HIV Infections, HIV-1, Humans, Lamivudine, Male, Organophosphonates, Reverse Transcriptase Inhibitors, RNA, Viral, Tenofovir, Viral Load
Abstract

BACKGROUND: Many trials of antiretroviral therapy in treatment-naïve subjects have investigated the relative efficacy of the third drug in a treatment regimen. However, the nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) components may also affect efficacy.

METHOD: A systematic overview of clinical trials studying initial treatment in naïve subjects receiving efavirenz-containing regimens and providing week 48 time to loss of virologic response (TLOVR) results was undertaken to compare results with different NRTI combinations.

RESULTS: Seven trials studying 3,807 subjects were identified that met the inclusion criteria. Baseline characteristics were similar across studies. Using the week 48 TLOVR results as the primary method of comparison, combinations of tenofovir and lamivudine or emtricitabine appeared to provide improved virologic responses. Similar results were obtained when the proportions of subjects with plasma HIV RNA levels <50 copies/mL were examined.

DOI10.1310/hct0804-221
Alternate JournalHIV Clin Trials
PubMed ID17720662
Grant ListAI062563 / AI / NIAID NIH HHS / United States
AI136156 / AI / NIAID NIH HHS / United States
AI64518 / AI / NIAID NIH HHS / United States
D43 TW06732 / TW / FIC NIH HHS / United States
K-24 AI01744 / AI / NIAID NIH HHS / United States