Lack of neutralizing antibody response to HIV-1 predisposes to superinfection.

TitleLack of neutralizing antibody response to HIV-1 predisposes to superinfection.
Publication TypeJournal Article
Year of Publication2006
AuthorsSmith DM, Strain MC, Frost SDW, Pillai SK, Wong JK, Wrin T, Liu Y, Petropolous CJ, Daar ES, Little SJ, Richman DD
JournalVirology
Volume355
Issue1
Pagination1-5
Date Published2006 Nov 10
ISSN0042-6822
KeywordsAdult, Case-Control Studies, HIV Antibodies, HIV-1, Humans, Middle Aged, Neutralization Tests, Superinfection
Abstract

Occurrences of HIV-1 superinfection offer a unique opportunity to investigate the correlates of immune protection. Here we describe the neutralizing antibody responses of a cohort of recently infected individuals who were screened for HIV superinfection. Three individuals identified with HIV superinfection had less cross-protective and autologous neutralizing antibody response than their non-superinfected case-controls. Neutralizing antibody may be crucial in the protection against superinfection and may explain why superinfection has only been documented following recent infection or treatment interruption. These data have considerable implications for vaccine development.

DOI10.1016/j.virol.2006.08.009
Alternate JournalVirology
PubMed ID16962152
Grant List5K23 AI055276 / AI / NIAID NIH HHS / United States
AI043638 / AI / NIAID NIH HHS / United States
AI047745 / AI / NIAID NIH HHS / United States
AI27670 / AI / NIAID NIH HHS / United States
AI29164 / AI / NIAID NIH HHS / United States
AI36214 / AI / NIAID NIH HHS / United States
U01AI38858 / AI / NIAID NIH HHS / United States