Title | Neurocognitive functioning and HAART in HIV and hepatitis C virus co-infection. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Parsons TD, Tucker KA, Hall CD, Robertson WT, Eron JJ, Fried MW, Robertson KR |
Journal | AIDS |
Volume | 20 |
Issue | 12 |
Pagination | 1591-5 |
Date Published | 2006 Aug 1 |
ISSN | 0269-9370 |
Keywords | Adult, Antiretroviral Therapy, Highly Active, Female, Hepatitis C, HIV Infections, Humans, Male, Memory Disorders, Motor Activity, Neuropsychological Tests, Patient Dropouts, Prospective Studies, Psychomotor Performance, Substance-Related Disorders |
Abstract | OBJECTIVES: This study examined the effects of HAART on neurocognitive functioning in persons with hepatitis C virus (HCV) and HIV co-infection. DESIGN: A prospective study examining neurocognitive performance before and after HAART initiation. METHOD: Participant groups included a mono-infected group (45 HIV+/HCV- participants) and a co-infected group (20 HIV+/HCV+ participants). A neuropsychological battery (attention/concentration, psychomotor speed, executive functioning, verbal memory, visual memory, fine motor, and gross motor functioning) was used to evaluate all participants. After 6 months of HAART, 31 HIV+ mono-infected and 13 HCV+/HIV+ co-infected participants were reevaluated. RESULTS: Neurocognitive functioning by domain revealed significantly worse performance in the co-infected group when compared to the monoinfected group on domains of visual memory and fine motor functioning. Assessment of neurocognitive functioning after antiretroviral therapy revealed that the co-infected group was no longer performing worse than the monoinfected group. CONCLUSIONS: The findings of the current study suggest that persons with HCV+/HIV+ co-infection may have greater neurocognitive declines than persons with HIV infection alone. HCV+/HIV+ co-infection may accelerate the progression of HIV related neurocognitive decline. |
DOI | 10.1097/01.aids.0000238404.16121.47 |
Alternate Journal | AIDS |
PubMed ID | 16868439 |
Grant List | 5R01MH062690-04 / MH / NIMH NIH HHS / United States 5R01NS036518-02 / NS / NINDS NIH HHS / United States 9P30 AI 50410-04 / AI / NIAID NIH HHS / United States AI-25868-15 / AI / NIAID NIH HHS / United States K24 DK066144 / DK / NIDDK NIH HHS / United States RR00046 / RR / NCRR NIH HHS / United States |