Neurocognitive functioning and HAART in HIV and hepatitis C virus co-infection.

TitleNeurocognitive functioning and HAART in HIV and hepatitis C virus co-infection.
Publication TypeJournal Article
Year of Publication2006
AuthorsParsons TD, Tucker KA, Hall CD, Robertson WT, Eron JJ, Fried MW, Robertson KR
Date Published2006 Aug 1
KeywordsAdult, Antiretroviral Therapy, Highly Active, Female, Hepatitis C, HIV Infections, Humans, Male, Memory Disorders, Motor Activity, Neuropsychological Tests, Patient Dropouts, Prospective Studies, Psychomotor Performance, Substance-Related Disorders

OBJECTIVES: This study examined the effects of HAART on neurocognitive functioning in persons with hepatitis C virus (HCV) and HIV co-infection.

DESIGN: A prospective study examining neurocognitive performance before and after HAART initiation.

METHOD: Participant groups included a mono-infected group (45 HIV+/HCV- participants) and a co-infected group (20 HIV+/HCV+ participants). A neuropsychological battery (attention/concentration, psychomotor speed, executive functioning, verbal memory, visual memory, fine motor, and gross motor functioning) was used to evaluate all participants. After 6 months of HAART, 31 HIV+ mono-infected and 13 HCV+/HIV+ co-infected participants were reevaluated.

RESULTS: Neurocognitive functioning by domain revealed significantly worse performance in the co-infected group when compared to the monoinfected group on domains of visual memory and fine motor functioning. Assessment of neurocognitive functioning after antiretroviral therapy revealed that the co-infected group was no longer performing worse than the monoinfected group.

CONCLUSIONS: The findings of the current study suggest that persons with HCV+/HIV+ co-infection may have greater neurocognitive declines than persons with HIV infection alone. HCV+/HIV+ co-infection may accelerate the progression of HIV related neurocognitive decline.

Alternate JournalAIDS
PubMed ID16868439
Grant List5R01MH062690-04 / MH / NIMH NIH HHS / United States
5R01NS036518-02 / NS / NINDS NIH HHS / United States
9P30 AI 50410-04 / AI / NIAID NIH HHS / United States
AI-25868-15 / AI / NIAID NIH HHS / United States
K24 DK066144 / DK / NIDDK NIH HHS / United States
RR00046 / RR / NCRR NIH HHS / United States