Efavirenz-based regimens in treatment-naive patients with a range of pretreatment HIV-1 RNA levels and CD4 cell counts.

TitleEfavirenz-based regimens in treatment-naive patients with a range of pretreatment HIV-1 RNA levels and CD4 cell counts.
Publication TypeJournal Article
Year of Publication2008
AuthorsRibaudo HJ, Kuritzkes DR, Lalama CM, Schouten JT, Schackman BR, Acosta EP, Gulick RM
JournalJ Infect Dis
Volume197
Issue7
Pagination1006-10
Date Published2008 Apr 1
ISSN0022-1899
KeywordsAdult, Anti-HIV Agents, Benzoxazines, CD4 Lymphocyte Count, Drug Therapy, Combination, Female, HIV Infections, Humans, Male, Reverse Transcriptase Inhibitors, RNA, Viral, Treatment Outcome, Viral Load
Abstract

The potency of 2 nucleoside reverse transcriptase inhibitors (NRTIs) and efavirenz in patients with higher viral loads (VLs) or low CD4 cell counts remains uncertain. Virologic failure and changes in CD4 count in relation to pretreatment VL and CD4 count were evaluated in treatment-naive patients randomized to treatment groups that received 2 or 3 NRTIs with efavirenz. Over 3 years, the risk of virologic failure was not significantly different among subgroups categorized according to pretreatment VL or CD4 count. No significant differences among subgroups were observed for CD4 count changes, except in patients with high pretreatment VL. There were no significant differences among subgroups with respect to treatment responses. These results demonstrate the potency of efavirenz-containing regimens across a spectrum of pretreatment VLs and CD4 counts.

DOI10.1086/529208
Alternate JournalJ. Infect. Dis.
PubMed ID18419537
Grant ListAI 51966 / AI / NIAID NIH HHS / United States
AI 69419 / AI / NIAID NIH HHS / United States
AI068636 / AI / NIAID NIH HHS / United States
AI27659 / AI / NIAID NIH HHS / United States
AI38858 / AI / NIAID NIH HHS / United States
AI69452 / AI / NIAID NIH HHS / United States
DA017179 / DA / NIDA NIH HHS / United States
M01RR024996 / RR / NCRR NIH HHS / United States
RR02635 / RR / NCRR NIH HHS / United States