Changes in the slope of the CD4 cell count increase after initiation of potent antiretroviral treatment.

TitleChanges in the slope of the CD4 cell count increase after initiation of potent antiretroviral treatment.
Publication TypeJournal Article
Year of Publication2006
AuthorsBosch RJ, Wang R, Vaida F, Lederman MM, Albrecht MA
JournalJ Acquir Immune Defic Syndr
Volume43
Issue4
Pagination433-5
Date Published2006 Dec 1
ISSN1525-4135
KeywordsAnti-HIV Agents, CD4 Lymphocyte Count, Drug Therapy, Combination, Female, HIV Infections, HIV-1, Humans, Male, Reverse Transcriptase Inhibitors, RNA, Viral, Treatment Outcome, Viral Load
Abstract

SUMMARY: Two phases of CD4+ T-cell increases are seen soon after potent antiretroviral therapy (ART) is initiated. In this 72-week analysis of 101 subjects with sustained viral suppression, we estimate the inflection point between the 2 phases to be 10 weeks after treatment initiation. Higher pretreatment HIV-1 RNA levels were associated with steeper initial CD4+ T-cell increases, likely reflecting greater redistribution of cells from lymphoid tissue to the peripheral blood compartment.

Alternate JournalJ. Acquir. Immune Defic. Syndr.
PubMed ID17183628
Grant ListAI 25879 / AI / NIAID NIH HHS / United States
AI 27659 / AI / NIAID NIH HHS / United States
AI 38855 / AI / NIAID NIH HHS / United States
AI 38858 / AI / NIAID NIH HHS / United States