A new approach for 'deep salvage' trials in advanced HIV infection.

TitleA new approach for 'deep salvage' trials in advanced HIV infection.
Publication TypeJournal Article
Year of Publication2007
AuthorsLederman MM, Miller V, Weller I, Deeks SG
Date Published2007 Jul 31
KeywordsAnti-HIV Agents, Clinical Trials as Topic, Drug Resistance, Multiple, Viral, HIV Infections, Humans, Research Design, Salvage Therapy

One of the most difficult problems in HIV care today is the management of individuals infected with multidrug-resistant viruses. Well-controlled, carefully designed clinical trials have recently resulted in the approval of several new antiviral agents for the treatment of drug-resistant HIV. The design of these trials has come at the cost of the predictable emergence of drug-resistant viruses among individuals randomly assigned to receive a suboptimal revised treatment regimen. We propose here a different approach to the evaluation of drug efficacy in individuals harbouring multidrug-resistant HIV.

Alternate JournalAIDS
PubMed ID17630543