Antiviral drug resistance.

TitleAntiviral drug resistance.
Publication TypeJournal Article
Year of Publication2006
AuthorsRichman DD
JournalAntiviral Res
Volume71
Issue2-3
Pagination117-21
Date Published2006 Sep
ISSN0166-3542
KeywordsAntiviral Agents, Drug Resistance, Viral, Evolution, Molecular, Herpesviridae, HIV-1, Humans, Mutation, Orthomyxoviridae, Viral Proteins
Abstract

Almost 30 years ago it was proposed that the selection for antiviral drug resistance should be used as an indicator of antiviral drug activity. In addition to discriminating between cellular toxicity and specific activity directed against a viral target, drug resistant mutants have been used to confirm the mechanism of action of antiviral drugs, to discover the functions of several viral proteins and to provide insights into viral evolution and fitness. Drug resistance has also become a standard component of both the preclinical and clinical drug development process. For HIV and increasingly for other viruses drug resistance testing has become standard-of-care in clinical practice. A few selected examples are provided to illustrate each of these points.

DOI10.1016/j.antiviral.2006.03.004
Alternate JournalAntiviral Res.
PubMed ID16621040
Grant ListAI 36214 / AI / NIAID NIH HHS / United States
AI043638 / AI / NIAID NIH HHS / United States
AI047745 / AI / NIAID NIH HHS / United States
AI27670 / AI / NIAID NIH HHS / United States
AI29164 / AI / NIAID NIH HHS / United States