Microbial translocation is a cause of systemic immune activation in chronic HIV infection.

TitleMicrobial translocation is a cause of systemic immune activation in chronic HIV infection.
Publication TypeJournal Article
Year of Publication2006
AuthorsBrenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, Kazzaz Z, Bornstein E, Lambotte O, Altmann D, Blazar BR, Rodriguez B, Teixeira-Johnson L, Landay A, Martin JN, Hecht FM, Picker LJ, Lederman MM, Deeks SG, Douek DC
JournalNat Med
Volume12
Issue12
Pagination1365-71
Date Published2006 Dec
ISSN1078-8956
KeywordsAnimals, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Bacterial Translocation, Cercocebus atys, Chronic Disease, Enterobacteriaceae, Feces, HIV Infections, HIV-1, Humans, Immune System, Lipopolysaccharides, Macaca mulatta, Simian Immunodeficiency Virus
Abstract

Chronic activation of the immune system is a hallmark of progressive HIV infection and better predicts disease outcome than plasma viral load, yet its etiology remains obscure. Here we show that circulating microbial products, probably derived from the gastrointestinal tract, are a cause of HIV-related systemic immune activation. Circulating lipopolysaccharide, which we used as an indicator of microbial translocation, was significantly increased in chronically HIV-infected individuals and in simian immunodeficiency virus (SIV)-infected rhesus macaques (P

DOI10.1038/nm1511
Alternate JournalNat. Med.
PubMed ID17115046
Grant ListAI 25879 / AI / NIAID NIH HHS / United States
AI 36219 / AI / NIAID NIH HHS / United States
AI 38858 / AI / NIAID NIH HHS / United States
AI052745 / AI / NIAID NIH HHS / United States
AI066998 / AI / NIAID NIH HHS / United States
AI41531 / AI / NIAID NIH HHS / United States
G108/441 / / Medical Research Council / United Kingdom
M01-RR0083-37 / RR / NCRR NIH HHS / United States
P30 AI27763 / AI / NIAID NIH HHS / United States
P30 MH62246 / MH / NIMH NIH HHS / United States
R0I AI052755 / AI / NIAID NIH HHS / United States
RR-00165 / RR / NCRR NIH HHS / United States
/ / Intramural NIH HHS / United States