Title | Preexisting resistance to nonnucleoside reverse-transcriptase inhibitors predicts virologic failure of an efavirenz-based regimen in treatment-naive HIV-1-infected subjects. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Kuritzkes DR, Lalama CM, Ribaudo HJ, Marcial M, Meyer WA, Shikuma C, Johnson VA, Fiscus SA, D'Aquila RT, Schackman BR, Acosta EP, Gulick RM |
Journal | J Infect Dis |
Volume | 197 |
Issue | 6 |
Pagination | 867-70 |
Date Published | 2008 Mar 15 |
ISSN | 0022-1899 |
Keywords | Adult, Benzoxazines, Case-Control Studies, Cohort Studies, Drug Administration Schedule, Drug Resistance, Multiple, Viral, Female, HIV Infections, HIV Reverse Transcriptase, HIV-1, Humans, Male, Reverse Transcriptase Inhibitors, Treatment Failure |
Abstract | A case-cohort study was used to determine the effect of baseline nonnucleoside reverse-transcriptase inhibitor (NNRTI) resistance, as assessed by viral genotyping, on the response to efavirenz-containing regimens in AIDS Clinical Trials Group A5095. The sample included a random cohort of efavirenz-treated subjects plus unselected subjects who experienced virologic failure. Of 220 subjects in the random cohort, 57 (26%) had virologic failure. The prevalence of baseline NNRTI resistance was 5%. The risk of virologic failure for subjects with baseline NNRTI resistance was higher than that for subjects without such resistance (hazard ratio 2.27 [95% confidence interval], 1.15-4.49; P = .018). These results support resistance testing before starting antiretroviral therapy. |
DOI | 10.1086/528802 |
Alternate Journal | J. Infect. Dis. |
PubMed ID | 18269317 |
Grant List | AI027767 / AI / NIAID NIH HHS / United States AI051966 / AI / NIAID NIH HHS / United States AI060354 / AI / NIAID NIH HHS / United States AI06836 / AI / NIAID NIH HHS / United States AI068636 / AI / NIAID NIH HHS / United States AI069419 / AI / NIAID NIH HHS / United States AI069452 / AI / NIAID NIH HHS / United States AI069472 / AI / NIAID NIH HHS / United States AI38858 / AI / NIAID NIH HHS / United States RR024996 / RR / NCRR NIH HHS / United States |