Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen.

TitlePatterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen.
Publication TypeJournal Article
Year of Publication2015
AuthorsLee AJ, Bosch RJ, Evans SR, Wu K, Harrison T, Grant P, Clifford DB
JournalJ Neurovirol
Volume21
Issue2
Pagination210-8
Date Published2015 Apr
ISSN1538-2443
KeywordsAnti-HIV Agents, CD4 Lymphocyte Count, Female, HIV Infections, Humans, Male, Middle Aged, Peripheral Nervous System Diseases, Young Adult
Abstract

The purpose of this study was to evaluate associations of pre-ART CD4 with peripheral neuropathy (PN) and estimate the prevalence of PN in HIV-positive patients starting modern combination antiretroviral therapy (cART) regimens. ART-naïve subjects initiating cART were followed longitudinally and screened for signs/symptoms of PN. Lower pre-ART CD4 count was associated with post-ART PN. After 7 years (n = 117), the prevalence (95% CI) of PN and SPN were 31% (23, 40%) and 5% (2, 11%) with pre-ART CD4 count >250 copies/μL. PN continues to be identified in HIV-infected individuals on modern cART by targeted assessment but is generally without symptoms.

DOI10.1007/s13365-015-0327-1
Alternate JournalJ. Neurovirol.
PubMed ID25678143
PubMed Central IDPMC4624403
Grant List1 U01 068634 / / PHS HHS / United States
NS32228 / NS / NINDS NIH HHS / United States
R01 NS032228 / NS / NINDS NIH HHS / United States
U01 AI068634 / AI / NIAID NIH HHS / United States
U01 AI068636 / AI / NIAID NIH HHS / United States
U01AI068636 / AI / NIAID NIH HHS / United States
UM1 AI068634 / AI / NIAID NIH HHS / United States
UM1 AI068636 / AI / NIAID NIH HHS / United States