Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals.

TitleAntiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals.
Publication TypeJournal Article
Year of Publication2015
AuthorsNaggie S, Patel K, Yang L-Y, Chow S-C, Johnson V, Guyton JR, Muir AJ, Sulkowski M, Hicks C
JournalOpen Forum Infect Dis
Volume2
Issue2
Paginationofv066
Date Published2015 Apr
ISSN2328-8957
Abstract

We evaluated the impact of antiretroviral-induced dyslipidemia on hepatitis C virus (HCV) biogenesis in human immunodeficiency virus (HIV)/HCV coinfected patients. This study used serum samples from antiretroviral-naive HIV/HCV patients initiating their first regimen as part of AIDS Clinical Trials Group study protocols (A5142, A5202). Initiation of antiretrovirals increased most lipoproteins and apolipoproteins. In the multivariable model, changes in apolipoproteins were associated with changes in log10 HCV RNA from baseline to week-24 of therapy. Off-target lipogenic changes need to be considered in the context of liver and other metabolic disease in HIV/HCV patients.

DOI10.1093/ofid/ofv066
Alternate JournalOpen Forum Infect Dis
PubMed ID26110167
PubMed Central IDPMC4473112
Grant ListP30 AI064518 / AI / NIAID NIH HHS / United States