Continued Slow Decay of the Residual Plasma Viremia Level in HIV-1-Infected Adults Receiving Long-term Antiretroviral Therapy.

TitleContinued Slow Decay of the Residual Plasma Viremia Level in HIV-1-Infected Adults Receiving Long-term Antiretroviral Therapy.
Publication TypeJournal Article
Year of Publication2016
AuthorsRiddler SA, Aga E, Bosch RJ, Bastow B, Bedison M, Vagratian D, Vaida F, Eron JJ, Gandhi RT, Mellors JW
Corporate AuthorsACTG A5276s Protocol Team
JournalJ Infect Dis
Volume213
Issue4
Pagination556-60
Date Published2016 Feb 15
ISSN1537-6613
KeywordsAdult, Anti-Retroviral Agents, Antiretroviral Therapy, Highly Active, CD4-CD8 Ratio, Female, HIV Infections, HIV-1, Humans, Longitudinal Studies, Male, Plasma, RNA, Viral, Viral Load
Abstract

UNLABELLED: We measured plasma human immunodeficiency virus type 1 (HIV-1) RNA levels by means of single-copy assay in 334 participants receiving virologically suppressive antiretroviral therapy (ART). A residual viremia load of ≥1 copy/mL after 4 years of ART was predicted by a higher pre-ART HIV-1 RNA level, higher CD8(+) T-cell count during treatment, and a lower ratio of CD4+ T cells to CD8+ T cells during treatment but not by initial ART regimen. In a longitudinal subset of 64 individuals, continued decay of the plasma HIV-1 RNA level was observed, with an average annual decrease of 6% and an estimated half-life of 11.5 years. In contrast to prior reports, the persistent viremia level continues to slowly decline during years 4-12 of suppressive ART.

CLINICAL TRIALS REGISTRATION: NCT00001137.

DOI10.1093/infdis/jiv433
Alternate JournalJ. Infect. Dis.
PubMed ID26333941
PubMed Central IDPMC4721905
Grant ListP30 MH062512 / MH / NIMH NIH HHS / United States
UM1 AI068634 / AI / NIAID NIH HHS / United States
UM1 AI068634 / AI / NIAID NIH HHS / United States
UM1 AI068636 / AI / NIAID NIH HHS / United States
UM1 AI068636 / AI / NIAID NIH HHS / United States
UM1 AI069423 / AI / NIAID NIH HHS / United States
UM1 AI069494 / AI / NIAID NIH HHS / United States
UM1 AI069534 / AI / NIAID NIH HHS / United States
UM1 AI106701 / AI / NIAID NIH HHS / United States