Persistently Elevated C-Reactive Protein Level in the First Year of Antiretroviral Therapy, Despite Virologic Suppression, Is Associated With HIV Disease Progression in Resource-Constrained Settings.

TitlePersistently Elevated C-Reactive Protein Level in the First Year of Antiretroviral Therapy, Despite Virologic Suppression, Is Associated With HIV Disease Progression in Resource-Constrained Settings.
Publication TypeJournal Article
Year of Publication2016
AuthorsShivakoti R, Yang W-T, Berendes S, Mwelase N, Kanyama C, Pillay S, Samaneka W, Santos B, Poongulali S, Tripathy S, Riviere C, Lama JR, Cardoso SW, Sugandhavesa P, Balagopal A, Gupte N, Semba RD, Campbell TB, Bollinger RC, Gupta A
Corporate AuthorsNWCS 319 and PEARLS study team
JournalJ Infect Dis
Volume213
Issue7
Pagination1074-8
Date Published2016 Apr 1
ISSN1537-6613
KeywordsAdult, Anti-HIV Agents, C-Reactive Protein, Case-Control Studies, Female, Global Health, HIV Infections, Humans, Inflammation, Male, Treatment Failure
Abstract

A case-cohort analysis of human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial measurements of CRP levels, and their association with HIV clinical failure. A persistently elevated CRP level in plasma (defined as ≥ 5 mg/L at both baseline and 24 weeks after ART initiation) was observed in 50 of 205 individuals (24%). A persistently elevated CRP level but not an elevated CRP level only at a single time point was independently associated with increased clinical failure, compared with a persistently low CRP level, despite achievement of virologic suppression. Serial monitoring of CRP levels could identify individuals who are at highest risk of HIV progression and may benefit from future adjunct antiinflammatory therapies.

DOI10.1093/infdis/jiv573
Alternate JournalJ. Infect. Dis.
PubMed ID26621909
PubMed Central IDPMC4779305
Grant ListR01AI080417 / AI / NIAID NIH HHS / United States
UM1AI068634 / AI / NIAID NIH HHS / United States
UM1AI068636 / AI / NIAID NIH HHS / United States
UM1AI069465 / AI / NIAID NIH HHS / United States
UM1AI106701 / AI / NIAID NIH HHS / United States