The lymph node in HIV pathogenesis.

TitleThe lymph node in HIV pathogenesis.
Publication TypeJournal Article
Year of Publication2008
AuthorsLederman MM, Margolis L
JournalSemin Immunol
Volume20
Issue3
Pagination187-95
Date Published2008 Jun
ISSN1044-5323
KeywordsAnimals, HIV Infections, HIV-1, Humans, Inflammation, Lymph Nodes, Simian Acquired Immunodeficiency Syndrome, T-Lymphocytes, Virus Replication
Abstract

Since the earliest days of the AIDS epidemic, clinicians and researchers have recognized the importance of lymphoid tissue both in the clinical manifestations of disease and in its pathogenesis. Generalized lymphadenopathy was one of the earliest harbingers of AIDS in the United States and over the past 27 years an increasing body of evidence has implicated the lymphoid organs as central to the pathogenesis of immune deficiency in chronic HIV-1 infection. In this essay, we will review some of the data that have been accumulated and propose a testable model that may reconcile them.

DOI10.1016/j.smim.2008.06.001
Alternate JournalSemin. Immunol.
PubMed ID18620868
PubMed Central IDPMC2577760
Grant ListP01 AI076174 / AI / NIAID NIH HHS / United States
P01 AI076174-01A1 / AI / NIAID NIH HHS / United States
P01 AI076174-01A18498 / AI / NIAID NIH HHS / United States
P30 AI036219 / AI / NIAID NIH HHS / United States
P30 AI036219-14S1 / AI / NIAID NIH HHS / United States
U01 AI025879 / AI / NIAID NIH HHS / United States
U01 AI025879-170004 / AI / NIAID NIH HHS / United States
U01 AI025879-179001 / AI / NIAID NIH HHS / United States
U01 AI025879-17S4 / AI / NIAID NIH HHS / United States
U01 AI069501 / AI / NIAID NIH HHS / United States
U01 AI069501-02 / AI / NIAID NIH HHS / United States