Peripheral neuropathy in ART-experienced patients: prevalence and risk factors.

TitlePeripheral neuropathy in ART-experienced patients: prevalence and risk factors.
Publication TypeJournal Article
Year of Publication2013
AuthorsChen H, Clifford DB, Deng L, Wu K, Lee AJ, Bosch RJ, Riddler SA, Ellis RJ, Evans SR
JournalJ Neurovirol
Volume19
Issue6
Pagination557-64
Date Published2013 Dec
ISSN1538-2443
KeywordsAdult, Anti-HIV Agents, CD4 Lymphocyte Count, Disease Progression, Drug Therapy, Combination, Female, HIV Infections, HIV-1, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Odds Ratio, Peripheral Nervous System Diseases, Prevalence, Risk Factors, Sex Factors
Abstract

Peripheral neuropathy (PN) is a common neurological complication of HIV infection that has debilitating effects on quality of life. While there has been a comprehensive evaluation of the prevalence of neuropathic signs/symptoms and risk factors (RFs) for PN or symptomatic PN (SPN) with initiation of combination antiretroviral therapy (cART) in ART-naïve patients, similar evaluation in ART-experienced patients is limited. This study investigated the prevalence and RFs for PN/SPN in ART-experienced patients enrolled in clinical salvage therapy studies. Between February 2000 and June 2007, 522 ART-experienced participants who experienced virologic failure with a prior regimen and started new regimens were followed longitudinally and annually screened for signs and symptoms of PN. Rates of PN/SPN at 3 years since parent study entry were 52.8 and 24.0 %, respectively. Aging, taller height, protease inhibitor use, and female sex were significant RFs for PN/SPN. The use of statin drugs was significantly associated with lower odds of SPN, and it may prevent progression from no SPN to SPN.

DOI10.1007/s13365-013-0216-4
Alternate JournalJ. Neurovirol.
PubMed ID24297499
PubMed Central IDPMC3965352
Grant List1 U01 068634 / / PHS HHS / United States
AI068636 / AI / NIAID NIH HHS / United States
NS32228 / NS / NINDS NIH HHS / United States
P30 MH062512 / MH / NIMH NIH HHS / United States
U01 AI068634 / AI / NIAID NIH HHS / United States
U01 AI068636 / AI / NIAID NIH HHS / United States
U01 NS032228 / NS / NINDS NIH HHS / United States
UM1 AI069494 / AI / NIAID NIH HHS / United States