High-grade anal intraepithelial neoplasia among HIV-1-infected men screening for a multicenter clinical trial of a human papillomavirus vaccine.

TitleHigh-grade anal intraepithelial neoplasia among HIV-1-infected men screening for a multicenter clinical trial of a human papillomavirus vaccine.
Publication TypeJournal Article
Year of Publication2013
AuthorsWilkin T, Lee JY, Lensing SY, Stier EA, Goldstone SE, Berry MJ, Jay N, Aboulafia DM, Einstein MH, Saah A, Mitsuyasu RT, Palefsky JM
JournalHIV Clin Trials
Volume14
Issue2
Pagination75-9
Date Published2013 Mar-Apr
ISSN1528-4336
KeywordsAcquired Immunodeficiency Syndrome, Adult, Anus Neoplasms, Carcinoma in Situ, CD4 Lymphocyte Count, HIV-1, Human papillomavirus 16, Humans, Male, Middle Aged, Papillomavirus Vaccines, Vaccination
Abstract

PURPOSE: High-grade anal intraepithelial neoplasia (HGAIN) is the precursor lesion to invasive anal cancer. Human papillomavirus (HPV) vaccination holds great promise for preventing anal cancer.

METHODS: We examined 235 HIV-1-infected men screening for participation in a multisite clinical trial of a quadrivalent HPV vaccine. All participants had anal swabs obtained for HPV testing and cytology and high-resolution anoscopy with biopsies of visible lesions to assess for HGAIN.

RESULTS: HPV types 16 and 18 were detected in 23% and 10%, respectively; abnormal anal cytology was found in 56% and HGAIN in 30%. HGAIN prevalence was significantly higher in those with HPV16 detection compared to those without (38% vs 17%; P = .01). Use of antiretroviral therapy and nadir and current CD4+ cell count were not associated with abnormal anal cytology or HGAIN.

CONCLUSION: HGAIN is highly prevalent in HIV-infected men. Further studies are needed on treatment and prevention of HGAIN.

DOI10.1310/hct1402-75
Alternate JournalHIV Clin Trials
PubMed ID23611828
PubMed Central IDPMC3676177
Grant ListK23 AI 55038 / AI / NIAID NIH HHS / United States
M01-RR00865 / RR / NCRR NIH HHS / United States
U01 CA121947 / CA / NCI NIH HHS / United States
U01 CA121947-01 / CA / NCI NIH HHS / United States
UL1 RR024131 / RR / NCRR NIH HHS / United States
UL1 RR024996 / RR / NCRR NIH HHS / United States
UL1 TR000457 / TR / NCATS NIH HHS / United States