Biomarkers of microbial translocation and macrophage activation: association with progression of subclinical atherosclerosis in HIV-1 infection.

TitleBiomarkers of microbial translocation and macrophage activation: association with progression of subclinical atherosclerosis in HIV-1 infection.
Publication TypeJournal Article
Year of Publication2012
AuthorsKelesidis T, Kendall MA, Yang OO, Hodis HN, Currier JS
JournalJ Infect Dis
Volume206
Issue10
Pagination1558-67
Date Published2012 Nov 15
ISSN1537-6613
KeywordsAdult, Anti-HIV Agents, Antigens, CD14, Atherosclerosis, Bacterial Translocation, Biomarkers, Cohort Studies, Female, HIV Infections, HIV-1, Humans, Lipopolysaccharides, Macrophage Activation, Male, Middle Aged, Protease Inhibitors, Retrospective Studies
Abstract

BACKGROUND: The relationships between soluble CD14 (sCD14), endotoxin (lipopolysaccharide [LPS]), and progression of atherosclerosis have not been defined in human immunodeficiency virus (HIV) infection.

METHODS: We retrospectively assessed serum sCD14 and LPS levels of 91 subjects in a prospective 3-year study of carotid artery intima-media thickness (CIMT) (AIDS Clinical Trials Group [ACTG] 5078), where subjects were enrolled as risk factor-controlled triads of HIV-uninfected (n = 36) and HIV-infected individuals with (n = 29) or without (n = 26) protease inhibitor (PI)-based therapy for ≥2 years. The primary end point was the yearly rate of change of CIMT (ΔCIMT).

RESULTS: In multivariate analysis of the HIV-infected subjects, each 1 µg/mL above the mean of baseline serum sCD14 corresponded to an additional 1.52 µm/y (95% confidence interval, .07-2.98; P = .04) in the ΔCIMT. Every 100 pg/mL above the mean of baseline serum LPS corresponded to an additional 0.49 µm/y (95% confidence interval, .18-.81; P = .003) in the ΔCIMT. However, in univariate analysis in the HIV-uninfected group sCD14 (P = .33) and LPS (P = .27) levels were not associated with higher ΔCIMT. HIV infection and PI therapy were not associated with baseline serum LPS and sCD14 levels (P > .1).

CONCLUSIONS: Our data are among the first to suggest that serum biomarkers of microbial translocation (LPS) and macrophage activation (sCD14) predict subclinical atherosclerosis progression in HIV-infected persons.

DOI10.1093/infdis/jis545
Alternate JournalJ. Infect. Dis.
PubMed ID23066162
PubMed Central IDPMC3475633
Grant List5R01HL095126 / HL / NHLBI NIH HHS / United States
AI056933 / AI / NIAID NIH HHS / United States
AI068634 / AI / NIAID NIH HHS / United States
AI28697 / AI / NIAID NIH HHS / United States
R01 HL095132 / HL / NHLBI NIH HHS / United States