The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection.

TitleThe virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection.
Publication TypeJournal Article
Year of Publication2010
AuthorsMarkowitz M, Vaida F, C Hare B, Boden D, Mohri H, Hecht FM, Kalayjian RC, Conrad A, Mildvan D, Aberg J, Hogan C, J Kilby M, Balfour HH, Schafer K, Richman D, Little S
JournalJ Infect Dis
Volume201
Issue9
Pagination1298-302
Date Published2010 May 1
ISSN1537-6613
KeywordsAdult, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Cyclosporine, Drug Therapy, Combination, Female, HIV Infections, HIV-1, Humans, Immunosuppressive Agents, Male, Viral Load
Abstract

Acute human immunodeficiency virus type 1 (HIV-1) infection is characterized by high levels of immune activation. Immunomodulation with cyclosporine combined with antiretroviral therapy (ART) in the setting of acute and early HIV-1 infection has been reported to result in enhanced immune reconstitution. Fifty-four individuals with acute and early infection were randomized to receive ART with 4 weeks of cyclosporine versus ART alone. In 48 subjects who completed the study, there were no significant differences between treatment arms in levels of proviral DNA or CD4(+) T cell counts. Adjunctive therapy with cyclosporine in this setting does not provide apparent virologic or immunologic benefit.

DOI10.1086/651664
Alternate JournalJ. Infect. Dis.
PubMed ID20235838
PubMed Central IDPMC2851487
Grant ListAI 27661 / AI / NIAID NIH HHS / United States
AI 27665 / AI / NIAID NIH HHS / United States
AI 46370 / AI / NIAID NIH HHS / United States
AI-69501 / AI / NIAID NIH HHS / United States
AI041534 / AI / NIAID NIH HHS / United States
AI069532 / AI / NIAID NIH HHS / United States
AI41530 / AI / NIAID NIH HHS / United States
AI41531 / AI / NIAID NIH HHS / United States
AI43638 / AI / NIAID NIH HHS / United States
M01RR00096 / RR / NCRR NIH HHS / United States
RR024143 / RR / NCRR NIH HHS / United States
U01 AI041534 / AI / NIAID NIH HHS / United States
U01 AI041534-05 / AI / NIAID NIH HHS / United States
U01 AI041534-06 / AI / NIAID NIH HHS / United States
U01 AI041534-07 / AI / NIAID NIH HHS / United States
U01 AI041534-08 / AI / NIAID NIH HHS / United States
U01 AI041534-09 / AI / NIAID NIH HHS / United States