African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy.

TitleAfrican mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy.
Publication TypeJournal Article
Year of Publication2010
AuthorsCanter JA, Robbins GK, Selph D, Clifford DB, Kallianpur AR, Shafer R, Levy S, Murdock DG, Ritchie MD, Haas DW, Hulgan T
Corporate AuthorsAIDS Clinical Trials Group Study 384 Team, New Work Concept Sheet 273 Team
JournalJ Infect Dis
Volume201
Issue11
Pagination1703-7
Date Published2010 Jun 1
ISSN1537-6613
KeywordsAdolescent, Adult, African Continental Ancestry Group, Aged, Antiretroviral Therapy, Highly Active, DNA, Mitochondrial, Female, Gene Frequency, Humans, Male, Middle Aged, Peripheral Nervous System Diseases, Reverse Transcriptase Inhibitors, Sequence Analysis, DNA, Young Adult
Abstract

Susceptibility to peripheral neuropathy during antiretroviral therapy with nucleoside reverse-transcriptase inhibitors was previously associated with a European mitochondrial DNA (mtDNA) haplogroup among non-Hispanic white persons. To determine whether nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy was related to mtDNA variation in non-Hispanic black persons, we sequenced mtDNA of participants from AIDS Clinical Trials Group study 384. Of 156 non-Hispanic black persons with genomic data, 51 (33%) developed peripheral neuropathy. In a multivariate model, African mtDNA subhaplogroup L1c was an independent predictor of peripheral neuropathy (odds ratio, 3.7 [95% confidence interval, 1.1-12.0]). An African mtDNA subhaplogroup is for the first time implicated in susceptibility to nucleoside reverse-transcriptase inhibitor-associated toxicity.

DOI10.1086/652419
Alternate JournalJ. Infect. Dis.
PubMed ID20402593
PubMed Central IDPMC2862090
Grant ListAI062435 / AI / NIAID NIH HHS / United States
AI069415 / AI / NIAID NIH HHS / United States
AI069419 / AI / NIAID NIH HHS / United States
AI069423 / AI / NIAID NIH HHS / United States
AI069424 / AI / NIAID NIH HHS / United States
AI069428 / AI / NIAID NIH HHS / United States
AI069432 / AI / NIAID NIH HHS / United States
AI069434 / AI / NIAID NIH HHS / United States
AI069450 / AI / NIAID NIH HHS / United States
AI069452 / AI / NIAID NIH HHS / United States
AI069465 / AI / NIAID NIH HHS / United States
AI069471 / AI / NIAID NIH HHS / United States
AI069472 / AI / NIAID NIH HHS / United States
AI069474 / AI / NIAID NIH HHS / United States
AI069477 / AI / NIAID NIH HHS / United States
AI069484 / AI / NIAID NIH HHS / United States
AI069495 / AI / NIAID NIH HHS / United States
AI069501 / AI / NIAID NIH HHS / United States
AI069502 / AI / NIAID NIH HHS / United States
AI069511 / AI / NIAID NIH HHS / United States
AI069513 / AI / NIAID NIH HHS / United States
AI069532 / AI / NIAID NIH HHS / United States
AI069556 / AI / NIAID NIH HHS / United States
AI077505 / AI / NIAID NIH HHS / United States
AI25859 / AI / NIAID NIH HHS / United States
AI27661 / AI / NIAID NIH HHS / United States
AI34835 / AI / NIAID NIH HHS / United States
AI34853 / AI / NIAID NIH HHS / United States
AI38844 / AI / NIAID NIH HHS / United States
AI46370 / AI / NIAID NIH HHS / United States
AI54999 / AI / NIAID NIH HHS / United States
AI69467 / AI / NIAID NIH HHS / United States
AI69495 / AI / NIAID NIH HHS / United States
AL32782 / / PHS HHS / United States
HL087726 / HL / NHLBI NIH HHS / United States
MH071205 / MH / NIMH NIH HHS / United States
NS059330 / NS / NINDS NIH HHS / United States
R21 NS059330 / NS / NINDS NIH HHS / United States
R21 NS059330-01 / NS / NINDS NIH HHS / United States
RR024975 / RR / NCRR NIH HHS / United States