MACH14: a multi-site collaboration on ART adherence among 14 institutions.

TitleMACH14: a multi-site collaboration on ART adherence among 14 institutions.
Publication TypeJournal Article
Year of Publication2013
AuthorsLiu H, Wilson IB, Goggin K, Reynolds N, Simoni JM, Golin CE, Rosen MI, Gross R, Wagner G, Remien RH, Schneiderman N, Erlen JA, Arnsten JH, Bangsberg DR
JournalAIDS Behav
Volume17
Issue1
Pagination127-41
Date Published2013 Jan
ISSN1573-3254
KeywordsAdolescent, Adult, Aged, Anti-HIV Agents, Clinical Trials as Topic, Cooperative Behavior, Data Collection, Female, HIV Infections, Humans, Information Systems, Male, Medication Adherence, Middle Aged, Socioeconomic Factors, Viral Load, Young Adult
Abstract

The integration of original data from multiple antiretroviral (ARV) adherence studies offers a promising, but little used method to generate evidence to advance the field. This paper provides an overview of the design and implementation of MACH14, a collaborative, multi-site study in which a large data system has been created for integrated analyses by pooling original data from 16 longitudinal ARV adherence studies. Studies selected met specific criteria including similar research design and data domains such as adherence measured with medication event monitoring system, psychosocial factors related to adherence behavior, and virologic and clinical outcomes. The data system created contains individual data (collected between 1997 and 2009) from 2,860 HIV patients. Collaboration helped resolve the challenges inherent in pooling data across multiple studies, yet produced a data system with strong statistical power and potentially greater capacity to address key scientific questions than possible with single-sample studies or even meta-analytic designs.

DOI10.1007/s10461-012-0272-4
Alternate JournalAIDS Behav
PubMed ID22864921
PubMed Central IDPMC3769091
Grant List2R01NR04749 / NR / NINR NIH HHS / United States
AI069419 / AI / NIAID NIH HHS / United States
AI38858 / AI / NIAID NIH HHS / United States
K02DA017277 / DA / NIDA NIH HHS / United States
K23MH01862 / MH / NIMH NIH HHS / United States
K24 MH092242 / MH / NIMH NIH HHS / United States
K24 RR020300 / RR / NCRR NIH HHS / United States
P01MH49548 / MH / NIMH NIH HHS / United States
P30 AI050410 / AI / NIAID NIH HHS / United States
P30 MH043520 / MH / NIMH NIH HHS / United States
R01 MH054907 / MH / NIMH NIH HHS / United States
R01 MH068197 / MH / NIMH NIH HHS / United States
R01 MH078773 / MH / NIMH NIH HHS / United States
R01 MH61173 / MH / NIMH NIH HHS / United States
R01AI41413 / AI / NIAID NIH HHS / United States
R01DA015679 / DA / NIDA NIH HHS / United States
R01DA11869 / DA / NIDA NIH HHS / United States
R01DA13826 / DA / NIDA NIH HHS / United States
R01DA15215 / DA / NIDA NIH HHS / United States
R01MH01584 / MH / NIMH NIH HHS / United States
R01MH078773 / MH / NIMH NIH HHS / United States
R01MH54907 / MH / NIMH NIH HHS / United States
R01MH58986 / MH / NIMH NIH HHS / United States
R01MH61695 / MH / NIMH NIH HHS / United States
R01MH68197 / MH / NIMH NIH HHS / United States
R01NR04749 / NR / NINR NIH HHS / United States