Detection of nonnucleoside reverse-transcriptase inhibitor-resistant HIV-1 after discontinuation of virologically suppressive antiretroviral therapy.

TitleDetection of nonnucleoside reverse-transcriptase inhibitor-resistant HIV-1 after discontinuation of virologically suppressive antiretroviral therapy.
Publication TypeJournal Article
Year of Publication2008
AuthorsC Hare B, Mellors J, Krambrink A, Su Z, Skiest D, Margolis DM, Patel SS, Barnas D, Frenkel L, Coombs RW, Aweeka F, Morse GD, Haas DW, Boltz V, Palmer S, Coffin J, Havlir DV
JournalClin Infect Dis
Volume47
Issue3
Pagination421-4
Date Published2008 Aug 1
ISSN1537-6591
KeywordsAdult, Drug Administration Schedule, Drug Resistance, Viral, Female, HIV Infections, HIV-1, Humans, Male, Mutation, Reverse Transcriptase Inhibitors, Viral Load
Abstract

Using standard and ultrasensitive techniques, we detected nonnucleoside reverse-transcriptase inhibitor-associated resistance mutations in 11 (20%) of 54 subjects who discontinued virologically suppressive nonnucleoside reverse-transcriptase inhibitor-containing antiretroviral therapy. Resistance was detected in 45% and 14% of subjects with a baseline human immunodeficiency virus type 1 RNA level of 51-400 copies/mL and

DOI10.1086/589867
Alternate JournalClin. Infect. Dis.
PubMed ID18558886
PubMed Central IDPMC2586907
Grant ListAI 32782 / AI / NIAID NIH HHS / United States
AI068634 / AI / NIAID NIH HHS / United States
AI25859 / AI / NIAID NIH HHS / United States
AI25868 / AI / NIAID NIH HHS / United States
AI25897 / AI / NIAID NIH HHS / United States
AI25903 / AI / NIAID NIH HHS / United States
AI25915 / AI / NIAID NIH HHS / United States
AI27658 / AI / NIAID NIH HHS / United States
AI27660 / AI / NIAID NIH HHS / United States
AI27661 / AI / NIAID NIH HHS / United States
AI27663 / AI / NIAID NIH HHS / United States
AI27664 / AI / NIAID NIH HHS / United States
AI27665 / AI / NIAID NIH HHS / United States
AI27666 / AI / NIAID NIH HHS / United States
AI27670 / AI / NIAID NIH HHS / United States
AI27673 / AI / NIAID NIH HHS / United States
AI27757 / AI / NIAID NIH HHS / United States
AI32783 / AI / NIAID NIH HHS / United States
AI34853 / AI / NIAID NIH HHS / United States
AI38858 / AI / NIAID NIH HHS / United States
AI39156 / AI / NIAID NIH HHS / United States
AI46339 / AI / NIAID NIH HHS / United States
AI46370 / AI / NIAID NIH HHS / United States
AI46381 / AI / NIAID NIH HHS / United States
AI46386 / AI / NIAID NIH HHS / United States
AI46736 / AI / NIAID NIH HHS / United States
AI50410 / AI / NIAID NIH HHS / United States
AI68634 / AI / NIAID NIH HHS / United States
R21 AI065288 / AI / NIAID NIH HHS / United States
R21 AI065288-01A1 / AI / NIAID NIH HHS / United States
RR00044 / RR / NCRR NIH HHS / United States
RR00046 / RR / NCRR NIH HHS / United States
RR00047 / RR / NCRR NIH HHS / United States
RR00095 / RR / NCRR NIH HHS / United States
RR00096 / RR / NCRR NIH HHS / United States
U01 AI038858 / AI / NIAID NIH HHS / United States
U01 AI068634 / AI / NIAID NIH HHS / United States