A pilot study to determine the impact on dyslipidemia of adding tenofovir to stable background antiretroviral therapy: ACTG 5206.

TitleA pilot study to determine the impact on dyslipidemia of adding tenofovir to stable background antiretroviral therapy: ACTG 5206.
Publication TypeJournal Article
Year of Publication2010
AuthorsTungsiripat M, Kitch D, Glesby MJ, Gupta SK, Mellors JW, Moran L, Jones L, Alston-Smith B, Rooney JF, Aberg JA
JournalAIDS
Volume24
Issue11
Pagination1781-4
Date Published2010 Jul 17
ISSN1473-5571
KeywordsAdenine, Adult, Aged, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Cholesterol, Dyslipidemias, Epidemiologic Methods, Female, HIV Infections, HIV-1, Humans, Male, Middle Aged, Organophosphonates, Pilot Projects, Tenofovir, Young Adult
Abstract

Several studies have reported improvement in lipids after antiretroviral therapy switches to tenofovir disoproxil fumarate (TDF)-containing regimens. We assessed lipid-lowering effects of TDF by adding it to a stable antiretroviral therapy regimen in this double-blind, placebo-controlled crossover study. We demonstrated that nonhigh-density lipoprotein cholesterol, low-density lipoprotein cholestrol, and total cholestrol improved significantly over TDF vs. placebo treatment in HIV-infected individuals with dyslipidemia. Adding TDF to stable, virologically suppressive antiretroviral therapy regimens improved lipid parameters, supporting a lipid-lowering effect of TDF.

DOI10.1097/QAD.0b013e32833ad8b4
Alternate JournalAIDS
PubMed ID20495438
PubMed Central IDPMC2913151
Grant List1 U01 AI 069494 / AI / NIAID NIH HHS / United States
AI-068634 / AI / NIAID NIH HHS / United States
AI-069494 / AI / NIAID NIH HHS / United States
AI-069501 / AI / NIAID NIH HHS / United States
AI-070078 / AI / NIAID NIH HHS / United States
AI-25859 / AI / NIAID NIH HHS / United States
AI-27665 / AI / NIAID NIH HHS / United States
AI068636 / AI / NIAID NIH HHS / United States
AI069419 / AI / NIAID NIH HHS / United States
AI069428 / AI / NIAID NIH HHS / United States
AI069532 / AI / NIAID NIH HHS / United States
AI078884 / AI / NIAID NIH HHS / United States
AI25859 / AI / NIAID NIH HHS / United States
AI27665 / AI / NIAID NIH HHS / United States
AI38558 / AI / NIAID NIH HHS / United States
K23 AI070078 / AI / NIAID NIH HHS / United States
K24 AI078884 / AI / NIAID NIH HHS / United States
K24 AI078884-03 / AI / NIAID NIH HHS / United States
M01 RR000096 / RR / NCRR NIH HHS / United States
M01 RR000096-478543 / RR / NCRR NIH HHS / United States
M01RR00096 / RR / NCRR NIH HHS / United States
U01 AI027665 / AI / NIAID NIH HHS / United States
U01 AI027665-18S2 / AI / NIAID NIH HHS / United States
U01 AI038858 / AI / NIAID NIH HHS / United States
U01 AI038858-09S6 / AI / NIAID NIH HHS / United States
U01 AI068634 / AI / NIAID NIH HHS / United States
U01 AI068634-04 / AI / NIAID NIH HHS / United States
U01 AI068636 / AI / NIAID NIH HHS / United States
U01 AI068636-01 / AI / NIAID NIH HHS / United States
U01 AI068636-02 / AI / NIAID NIH HHS / United States
U01 AI068636-03 / AI / NIAID NIH HHS / United States
U01 AI068636-04 / AI / NIAID NIH HHS / United States
U01 AI069501 / AI / NIAID NIH HHS / United States
U01 AI069501-04 / AI / NIAID NIH HHS / United States
U01 AI069532 / AI / NIAID NIH HHS / United States
U01 AI069532-01 / AI / NIAID NIH HHS / United States
U01 AI069532-02 / AI / NIAID NIH HHS / United States
U01 AI069532-03 / AI / NIAID NIH HHS / United States
U01 AI069532-04 / AI / NIAID NIH HHS / United States
U01AI069495 / AI / NIAID NIH HHS / United States