Reanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity.

TitleReanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity.
Publication TypeJournal Article
Year of Publication2011
AuthorsWilkin TJ, Goetz MBidwell, Leduc R, Skowron G, Su Z, Chan ES, Heera J, Chapman D, Spritzler J, Reeves JD, Gulick RM, Coakley E
JournalClin Infect Dis
Volume52
Issue7
Pagination925-8
Date Published2011 Apr 1
ISSN1537-6591
KeywordsAdult, HIV Infections, HIV-1, Humans, Receptors, CCR5, Receptors, CXCR4, Receptors, HIV, Viral Tropism, Virology, Virus Attachment
Abstract

The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CXCR4-using virus in all cohorts.

DOI10.1093/cid/cir072
Alternate JournalClin. Infect. Dis.
PubMed ID21427401
PubMed Central IDPMC3106234
Grant ListAI-46381 / AI / NIAID NIH HHS / United States
AI-68634 / AI / NIAID NIH HHS / United States
AI-69419 / AI / NIAID NIH HHS / United States
K23 AI55038 / AI / NIAID NIH HHS / United States
K24 AI051966 / AI / NIAID NIH HHS / United States
K24 AI51966 / AI / NIAID NIH HHS / United States
R44AI050321 / AI / NIAID NIH HHS / United States
RR024996 / RR / NCRR NIH HHS / United States
U01 AI-42170 / AI / NIAID NIH HHS / United States
U01 AI-46362 / AI / NIAID NIH HHS / United States
U01 AI-68636 / AI / NIAID NIH HHS / United States
U01 AI-68641 / AI / NIAID NIH HHS / United States