Simplification of the research diagnosis of HIV-associated sensory neuropathy.

TitleSimplification of the research diagnosis of HIV-associated sensory neuropathy.
Publication TypeJournal Article
Year of Publication2008
AuthorsEvans SR, Clifford DB, Kitch DW, Goodkin K, Schifitto G, McArthur JC, Simpson DM
JournalHIV Clin Trials
Volume9
Issue6
Pagination434-9
Date Published2008 Nov-Dec
ISSN1528-4336
KeywordsElectrophysiology, Female, HIV Infections, Humans, Male, Middle Aged, Neural Conduction, Neurologic Examination, Peripheral Nervous System Diseases, Sensation Disorders, Sensitivity and Specificity
Abstract

Peripheral neuropathy (PN) is the most common neurological complication of HIV infection,affecting over one third of patients. The research diagnosis of PN is complicated by the need for expensive, time-consuming, and noxious diagnostic tests. We investigated whether nerve conduction studies (NSC) and quantitative sensory tests (QST) provide added value for the diagnosis of PN for research purposes or whether the easily obtainable clinical measures (sensory and motor symptoms, sensitivity to pain and vibration, tendon reflexes, motor function) are sufficient.

DOI10.1310/hct0906-434
Alternate JournalHIV Clin Trials
PubMed ID19203909
PubMed Central IDPMC2684847
Grant List1 U01 068634 / / PHS HHS / United States
2 U01 NS0322228-08A1 / NS / NINDS NIH HHS / United States
5 U01 AI038855-08 / AI / NIAID NIH HHS / United States
K24 NS002253-05 / NS / NINDS NIH HHS / United States
K24NS02253 / NS / NINDS NIH HHS / United States
NS44807 / NS / NINDS NIH HHS / United States
R01 NS044807 / NS / NINDS NIH HHS / United States
R01 NS044807-05 / NS / NINDS NIH HHS / United States
RR-00071 / RR / NCRR NIH HHS / United States
U01 AI038855 / AI / NIAID NIH HHS / United States
U01 AI038855-08 / AI / NIAID NIH HHS / United States
U01 AI068634 / AI / NIAID NIH HHS / United States
U01 AI068634-03 / AI / NIAID NIH HHS / United States
U01 NS032228 / NS / NINDS NIH HHS / United States
U01 NS032228-08A1 / NS / NINDS NIH HHS / United States