Proteinuria, creatinine clearance, and immune activation in antiretroviral-naive HIV-infected subjects.

TitleProteinuria, creatinine clearance, and immune activation in antiretroviral-naive HIV-infected subjects.
Publication TypeJournal Article
Year of Publication2009
AuthorsGupta SK, Komarow L, Gulick RM, Pollard RB, Robbins GK, Franceschini N, Szczech LA, Koletar SL, Kalayjian RC
JournalJ Infect Dis
Volume200
Issue4
Pagination614-8
Date Published2009 Aug 15
ISSN0022-1899
KeywordsAdult, Anti-HIV Agents, CD8-Positive T-Lymphocytes, Creatinine, Cross-Sectional Studies, Female, HIV Infections, Humans, Male, Proteinuria
Abstract

Because both renal disease and immune activation predict progression to acquired immunodeficiency syndrome (AIDS), we evaluated the associations between proteinuria>or=1+, as determined by dipstick analysis (7 [7%] of 1012 subjects); creatinine clearance of <90 mL/min (195 [18%] of 1071 subjects); and percentages of peripheral activated CD8 cells (CD8+CD38+HLA-DR+ cells) in antiretroviral-naive, human immunodeficiency virus (HIV)-infected subjects who were enrolled in AIDS Clinical Trials Group studies 384 and A5095. Proteinuria, but not creatinine clearance, was associated with higher percentages of CD8+CD38+HLA-DR+ cells (55% vs. 50%; P=.01), with even more pronounced differences noted among men and among blacks and Hispanics. Proteinuria may be a surrogate measurement of greater immune activation in HIV-infected patients initiating antiretroviral therapy.

DOI10.1086/600890
Alternate JournalJ. Infect. Dis.
PubMed ID19591572
PubMed Central IDPMC2858634
Grant ListAI-68634 / AI / NIAID NIH HHS / United States
K01 AI-062435 / AI / NIAID NIH HHS / United States
K01 AI062435 / AI / NIAID NIH HHS / United States
K01 AI062435-01A1 / AI / NIAID NIH HHS / United States
K23 HL-073682 / HL / NHLBI NIH HHS / United States
K23 HL073682 / HL / NHLBI NIH HHS / United States
K23 HL073682-05 / HL / NHLBI NIH HHS / United States
K24 AI-51966 / AI / NIAID NIH HHS / United States
K24 AI051966 / AI / NIAID NIH HHS / United States
K24 AI051966-01A1 / AI / NIAID NIH HHS / United States
U01 AI068634 / AI / NIAID NIH HHS / United States
U01 AI068634-01 / AI / NIAID NIH HHS / United States
U01 AI068636 / AI / NIAID NIH HHS / United States
U01 AI068636-01 / AI / NIAID NIH HHS / United States
U01-AI-68636 / AI / NIAID NIH HHS / United States