HIV-1 drug resistance genotype results in patients with plasma samples with HIV-1 RNA levels less than 75 copies/mL.

TitleHIV-1 drug resistance genotype results in patients with plasma samples with HIV-1 RNA levels less than 75 copies/mL.
Publication TypeJournal Article
Year of Publication2006
AuthorsMitsuya Y, Winters MA, W Fessel J, Rhee S-Y, Slome S, Flamm J, Horberg M, Hurley L, Klein D, Shafer RW
JournalJ Acquir Immune Defic Syndr
Volume43
Issue1
Pagination56-9
Date Published2006 Sep
ISSN1525-4135
KeywordsAnti-HIV Agents, Drug Resistance, Viral, Genotype, HIV Infections, HIV-1, Humans, Phylogeny, RNA, Viral, Viral Load
Abstract

HIV-1 genotypic resistance test results were obtained on clinical samples from 116 patients with plasma HIV-1 RNA levels of less than 75 copies/mL. Genotype validity was confirmed in 49 of 50 patients with a previous or follow-up genotype. The belief that genotypic resistance testing is unreliable in samples with low-level viremia should be reassessed.

DOI10.1097/01.qai.0000232609.99705.a2
Alternate JournalJ. Acquir. Immune Defic. Syndr.
PubMed ID16885777
PubMed Central IDPMC2547468
Grant ListR01 AI046148 / AI / NIAID NIH HHS / United States
R01 AI046148-08 / AI / NIAID NIH HHS / United States