Body mass index and CD4+ T-lymphocyte recovery in HIV-infected men with viral suppression on antiretroviral therapy.

TitleBody mass index and CD4+ T-lymphocyte recovery in HIV-infected men with viral suppression on antiretroviral therapy.
Publication TypeJournal Article
Year of Publication2011
AuthorsPalermo B, Bosch RJ, Bennett K, Jacobson JM
JournalHIV Clin Trials
Volume12
Issue4
Pagination222-7
Date Published2011 Jul-Aug
ISSN1528-4336
KeywordsAdult, Anti-Retroviral Agents, Body Mass Index, CD4 Lymphocyte Count, HIV Infections, Humans, Leptin, Male, Middle Aged
Abstract

PURPOSE: To better characterize the relationship between body mass index (BMI) and CD4+ T-lymphocyte recovery in HIV disease.

METHODS: We analyzed the association between baseline BMI and CD4+ T-lymphocyte increases, as well as the association between BMI and immune activation (CD38 and HLA-DR co-expression on CD4+ and CD8+ T-lymphocytes), in male HIV-infected patients who achieved viral suppression on antiretroviral therapy (ART).

RESULTS: Baseline BMI predicted change in CD4+ T-lymphocyte count at weeks 96 ( P = .03, n = 461) and 144 ( P = .005, n = 357) but not at week 48 ( P = .38, n = 558). Relative to men with a normal BMI, overweight and obese men had increases at week 144 that were 35 and 113 cells/ mm3 higher, respectively, while underweight men had CD4+ T-lymphocyte increases that were 94 cells/mm3 lower. No significant correlations between baseline BMI and cellular immune activation were seen.

CONCLUSIONS: BMI predicts CD4+ T-lymphocyte gains in men started on ART.

DOI10.1310/HCT1204-222
Alternate JournalHIV Clin Trials
PubMed ID22044858
PubMed Central IDPMC3342850
Grant ListAI-38855 / AI / NIAID NIH HHS / United States
AI-38858 / AI / NIAID NIH HHS / United States
AI-68634 / AI / NIAID NIH HHS / United States
AI-68636 / AI / NIAID NIH HHS / United States
U01 AI038855 / AI / NIAID NIH HHS / United States
U01 AI038855-04 / AI / NIAID NIH HHS / United States
U01 AI038858 / AI / NIAID NIH HHS / United States
U01 AI038858-04 / AI / NIAID NIH HHS / United States
U01 AI068634 / AI / NIAID NIH HHS / United States
U01 AI068634-01 / AI / NIAID NIH HHS / United States
U01 AI068636 / AI / NIAID NIH HHS / United States
U01 AI068636-01 / AI / NIAID NIH HHS / United States