A novel codon insert in protease of clade B HIV type 1.

TitleA novel codon insert in protease of clade B HIV type 1.
Publication TypeJournal Article
Year of Publication2009
AuthorsJordan PS, Poon A, Eron J, Squires K, Ignacio C, Richman DD, Smith DM
JournalAIDS Res Hum Retroviruses
Volume25
Issue5
Pagination547-50
Date Published2009 May
ISSN1931-8405
KeywordsBase Sequence, HIV Infections, HIV Protease, HIV Reverse Transcriptase, HIV-1, Humans, Models, Molecular, Molecular Sequence Data, Mutagenesis, Insertional, RNA, Viral, Sequence Analysis, DNA
Abstract

A novel combination of three codon inserts in the pol coding region of HIV-1 RNA was identified in a highly antiretroviral experienced study subject with HIV-1 infection. A one codon insert was observed in the protease region between codon 40 and 41 simultaneously with a two codon insert present in the reverse transcriptase region at codon 69.

DOI10.1089/aid.2008.0310
Alternate JournalAIDS Res. Hum. Retroviruses
PubMed ID19397401
PubMed Central IDPMC2749665
Grant ListAI043638 / AI / NIAID NIH HHS / United States
AI047745 / AI / NIAID NIH HHS / United States
AI069464 / AI / NIAID NIH HHS / United States
AI077304 / AI / NIAID NIH HHS / United States
AI36214 / AI / NIAID NIH HHS / United States
AI50410 / AI / NIAID NIH HHS / United States
AI69423 / AI / NIAID NIH HHS / United States
AI69432 / AI / NIAID NIH HHS / United States
AI74621 / AI / NIAID NIH HHS / United States
MH083552 / MH / NIMH NIH HHS / United States
MH62512 / MH / NIMH NIH HHS / United States
P01 AI074621 / AI / NIAID NIH HHS / United States
P01 AI074621-01A10002 / AI / NIAID NIH HHS / United States
P30 AI036214 / AI / NIAID NIH HHS / United States
P30 AI036214-16 / AI / NIAID NIH HHS / United States
P30 AI050410 / AI / NIAID NIH HHS / United States
P30 AI050410-129002 / AI / NIAID NIH HHS / United States
P30 MH062512 / MH / NIMH NIH HHS / United States
P30 MH062512-069008 / MH / NIMH NIH HHS / United States
R01 AI047745 / AI / NIAID NIH HHS / United States
R01 AI047745-06 / AI / NIAID NIH HHS / United States
R01 MH083552 / MH / NIMH NIH HHS / United States
R21 AI077304 / AI / NIAID NIH HHS / United States
U01 AI043638 / AI / NIAID NIH HHS / United States
U01 AI043638-08 / AI / NIAID NIH HHS / United States
U01 AI069423 / AI / NIAID NIH HHS / United States
U01 AI069423-02 / AI / NIAID NIH HHS / United States
U01 AI069432 / AI / NIAID NIH HHS / United States
U01 AI069432-02 / AI / NIAID NIH HHS / United States
U01 AI069464-02 / AI / NIAID NIH HHS / United States